Prem, Chand (2016) Role of Diffusion Tensor Imaging in epilepsy. Masters thesis, Stanley Medical College, Chennai.
|
Text
2008002premchand.pdf Download (10MB) | Preview |
Abstract
BACKGROUND: Diffusion Tensor Imaging (DTI) is a new non invasive MRI technique which provides insight into the white matter microstructure. In focal epilepsy widespread DTI abnormalities have been reported. In mesial temporal lobe sclerosis (MTLS) patients, although conventional MRI only shows unilateral involvement of the hippocampal sclerosis, DTI was found to be useful in demonstrating the spread of epileptiform activity to other regions of brain as well. AIM AND OBJECTIVES: We aimed to prove this hypothesis by assessing DTI measurements in various portions of the brain in MTLS patients. MATERIAL AND METHODS: We retrospectively evaluated 21 patients with unilateral MTLS by using DTI, MRI, clinical and EEG parameters. Of these 10 were Right sided and 11 were left sided MTLS. We compared the mean diffusivity (trace D) and fractional anisotropy (FA) from symmetrical voxels by sampling the following areas namely middle cerebellar peduncle, corpus callosum, uncinate fasciculus, inferior fronto occipital fasciculus, inferior temporo-occipital fasciculus, parahippocampal white matter, fimbria and fornix, hippocampus cingulated gyrus, thalamus, internal capsule, caudate and lentiform nucleus. We compared these measurements with the EEG, high-resolution MR imaging, and clinical information. RESULTS: There was statistically significant decrease in FA values with increased mean diffusivity was seen in the regions beyond the structurally abnormal hippocampus which could not be picked up by conventional MRI. CONCLUSION: DTI is highly sensitive to cortical micro structural changes that underlie epilepsy. DTI is an important radiological tool in the pre surgical evaluation of epilepsy and surgical planning.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Diffusion Tensor Imaging (DTI) ; Epilepsy. |
| Subjects: | MEDICAL > Radio Diagnosis |
| Depositing User: | Punitha K |
| Date Deposited: | 12 Jul 2017 12:11 |
| Last Modified: | 09 Dec 2018 06:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1549 |
Actions (login required)
 |
View Item |
