Ramesh Aravindh, M (2023) A Study on Etiology and Clinical Outcome of Hyponatremia Patients admitted in ICU in Tirunelveli Medical College Hospital. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
INTRODUCTION: Hyponatremia remains poorly understood in many basic aspects, because of its connection with a plethora of underlying disease conditions, and its numerous aetiologies with differing pathophysiological conditions. Without addressing this problem carefully and methodically, the prognostic implications of the problem are lethal and far-reaching. Early recognition of hyponatremia and appropriate intervention would improve the outcome. OBJECTIVES: To study the aetiology, clinical presentation, outcomes and associated factors of hyponatremia in ICU patients. METHODOLOGY: This is a hospital based cross sectional study, 100 patients admitted in IMCU admitted under the Department of General Medicine, Tirunelveli Medical College, with serum sodium less than 135 mmol/L. After the detailed history, thorough clinical examination, the following biochemical parameters are collected using a pre-structured proforma. Details of comorbidities associated symptoms and blood and urine parameters were compared with outcomes of hyponatremia. RESULTS: Among the study subjects, 45 (45%) were Euvolemic followed by 30 (30%) were Hypervolemic and least 25 (25%) were Hypovolemic hyponatremia. Diabetes Mellitus and Hypertension were the most common comorbidities. Vomiting (43%) altered sensorium (35%) and headache (34%) were the most common presenting symptoms. 40 (40%) were due to SIADH followed by 30 (30%) were due to Volume Overload were the common cause of hyponatremia. The mortality rate among our study population was 10%. Increased age, Euvolemic and hypovolemic hyponatremia, Presence of headache, seizures, and vomiting, Higher urine sodium levels and lower creatinine levels were significantly associated with the higher mortality in hyponatremia. Male gender, Hyponatremia due to SIADH, Presence of diabetes, hypertension and coronary heart disease, presence of diarrhea and altered sensorium associated with the higher mortality in hyponatremia, but not statistically significant. TFT, Co-Syntropin Test, serum sodium, Serum & Urine Osmolality, Serum urea and Random blood sugar was not associated with the mortality in hyponatremia. CONCLUSION: Mortality rates are higher in hyponatremia, and is associated with the Increased age, Euvolemic and hypovolemic hyponatremia, Presence of headache, seizures, and vomiting, Higher urine sodium levels and lower creatinine levels.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.200120104014 |
| Uncontrolled Keywords: | Etiology, Clinical Outcome, Hyponatremia Patients, ICU, TVMCH. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Apr 2021 12:40 |
| Last Modified: | 25 Mar 2024 02:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/15324 |
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