Prevalence and Detection of Leptospirosis among Voluntary Blood Donors

Jeevapriya, R (2010) Prevalence and Detection of Leptospirosis among Voluntary Blood Donors. Masters thesis, The Tamil Nadu Dr. M.G.R. Medical University, Chennai.


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Blood transfusion is an important part of modern medicine and often a life – saving procedure. But it carries the major risk of transmission of infections because of large volume of human source material is infused directly into the body and blood collected from a single infectious donor may be transfused to a large number of recipients.1 Transfusion transmissible agents have certain characteristics. They are present in an infectious or potentially infectious form in the blood, and are stable during storage and transmitted via the parenteral route. Most importantly, they can cause asymptomatic infections in the donor and an apparently healthy prospective donor could potentially be harboring infections. Prevalence of leptospirosis among voluntary blood donors in our study was found to be 21%. • Of the 100 samples studied, 31 were positive by DFM, 40 by MAT, 21 by both DFM and MAT; however, none of the samples were found positive by PCR. • Leptospira survived for 48 hrs in stored plasma at 4-6°C and 24 hrs in fresh frozen plasma stored at -18oC. • DFM technique can be used as a simple, rapid and inexpensive means of leptospira detection. • Leptospiral screening can be made mandatory in endemic regions like Chennai after undertaking a larger study.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Prevalence ; Detection ; Leptospirosis ; Voluntary Blood Donors
Subjects: MEDICAL > Immunohaematology Blood Transfusion
Depositing User: Kambaraman B
Date Deposited: 21 Jun 2017 06:30
Last Modified: 16 Jun 2019 02:13

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