Smylin Ajitha Rani, S (2012) Synthesis, Characterization and Biological activity of 1,3,4- Oxadiazole and 1,3,4- Thiadiazole Derivatives. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
Various substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives have been synthesized by cyclising semicarbazone and thiosemicarbazone in presence of ferric chloride and citric acid to form 2-amino-5-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole respectively. These derivatives undergoes mannich reaction with substituted aniline and formaldehyde to form 2-amino5-substituted1,3,4-oxadiazole and 1,3,4- thiadiazole derivatives. The identity of compounds were confirmed on the basis of their spectral(IR,1H NMR and MASS) data. Further, they have been screened for their antibacterial, antifungal, anticancer and antitubercular activities.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Synthesis; Characterization; Biological Activity; Oxadiazole; Thiadiazole Derivatives |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 12 Jul 2017 06:37 |
| Last Modified: | 12 Oct 2017 03:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1525 |
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