Detection of Alloantibodies in Multiply Transfused Thalassemia Major Patients.

Joshua Daniel Jeyakumar, M (2009) Detection of Alloantibodies in Multiply Transfused Thalassemia Major Patients. Masters thesis, The Tamil Nadu Dr. M.G.R. Medical University, Chennai.


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Thalassemia is a common condition, particularly in the meditermean region and southeast Asia. The term ‘thalassemia’ is used to describe a disorder with a significant decrease in the synthesis of one or more globin chains. Thalassemia is the most common single gene disorder in the world. Thalassemia has an autosomal recessive pattern of inheritance. It arises from mutation or deletion in one or more globin gene(s), leading to varying degrees of anemia that can range from insignificance to life threatening event. Life long red cell transfusion remains the main treatment for thalassemia. The recommended treatment for beta-thalassemia major is regular blood transfusion every three to four weeks, with a goal to correct anemia, to significantly suppress the hyperactive erythropoiesis and to inhibit gastrointestinal iron absorption3. The use of regular blood transfusion and iron chelation therapy has led thalassemia major from fatal disease in early childhood to a chronic illness with prolonged survival. This study was conducted on 51 registered thalassemia major patients for the presence of alloantibody to red cell antigens.  26 patients were males and 25 of them were females. Majority of the patients had maintained a pretransfusion hemoglobin of 7 – 9.5 gm/dl.  70% of the study population were below 14 yrs of age.  94% of the study population were ethnically identical with the donor.  All the transfused units were leukocyte reduced.  Most of the patients had their transfusion once every 21 days.  None of the 51 patients developed alloantibody to any of the red cell antigens.  Six of the patients had transfusion transmitted hepatitis C virus and one patient had HIV virus infection.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Detection of Alloantibodies; Multiply Transfused Thalassemia; Patients
Subjects: MEDICAL > Immunohaematology Blood Transfusion
Depositing User: Kambaraman B
Date Deposited: 21 Jun 2017 06:23
Last Modified: 16 Jun 2019 02:10

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