Kohila, G (2022) To Study the Fetomaternal Outcome and Complications in Pregnancy with Moderate and Severe Splenomegaly. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
Splenomegaly in pregnancy is commonly seen in endemic countries like India , however, Studies regarding outcome and management of splenomegaly in pregnancy is still lacking. Our study attempts to document the clinical, radiological and etiological profile of splenomegaly in pregnant patients. It also analyses the outcome, complications of pregnant mother and various treatment modalities followed in our hospital. Also outcome of fetus is also observed. • Age distribution does not specific association with occurance of splenomegaly. Primigravida was more common in our study group. • Thrombocytopenia and gestational hypertension are the common associated /risk factors observed along with splenomegaly in our study group. • Splenomegaly was present and diagnosed during and after pregnancy when compared prior to pregnancy itself in our study group with significant statistical association. • Particularly, splenomegaly was maximally found and diagnosed in 3rd trimester of pregnancy in 46.67% of population and this association displayed statistical significance. • Moderate splenomegaly (76.67) was more common than massive enlargement of spleen (23.3%) in our study group. • Co-existent anaemia, thrombocytopenia and coagulation abnormalities are haematological manifestations seen in our study group. • Radiological features (USG and portal vein Doppler) contributing to etiology were usg findings – etiology and percentage in our study: Portal vein thrombosis - 10%, Portal vein cavernoma - 10%, Portal hypertension - 20%, Parenchymal liver disease - 6.67%, Extra hepatic portal vein obstruction - 13.33%, Non cirrhotic portal fibrosis - 3.33%. • Etiological is similar to that given by study by seem singhal et al (15) and Hoffbrand AV [et al]. • Complications of splenomegaly such as collaterals and oesophageal varices were observed in Doppler studies and endoscopy. • Severe thrombocytopenia, PPH, Hematemesis, AKI, abortions were the postnatal complications observed commonly in splenomegaly mothers. • They were commonly treated with supportive transfusion either platelets, packed red blood cells, FFP, cryo according to the clinical presentation. • Post natal blood transfusion were more common than antenatal transfusion and treatment of transfusion correlates with the presence of postnatal complication with statistical significance. • Fatal outcome in mother was observed in 1 patient in our study group. • Fetal outcome of preterm delivery, IUGR, very low birth weight, SGA are common in splenomegaly mothers and warrants SNN admission in our study • Also, abortions (13%) and fetal death (6.67%) were observed in our study group of splenomegaly mothers • However, outcome in mother or foetus does not correlate with the grading and severity of splenomegaly in our study group. Thus we observed the complete clinical profile of splenomegaly with pregnancy patients and still the obstetric complications encountered and treatment should be studied in detail further.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221916356 |
| Uncontrolled Keywords: | Fetomaternal Outcome, Complications, Pregnancy, Moderate, Severe Splenomegaly. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology > MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 24 Apr 2021 13:13 |
| Last Modified: | 10 Dec 2023 03:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/15157 |
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