Rigana Murshidha, R (2012) Molecular Modelling, Synthesis, Characterization & Biological Evaluation Of Some Novel 2-Phenyl 3-Substituted Amino Quinazolin 4(3h)-Ones. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
Medicinal Chemistry is a science whose roots lie in all branches of chemistry and biology. Pharmaceutical Chemistry is a branch of Science that makes use of the general law of chemistry to study drugs (ie) their preparation, chemical nature, composition, studies of their physical and chemical proportion, method of quality control and the conditions of their usages. Novel 2-phenyl 3-substituted amino quinazolin-4(3H)ones were synthesized by a 3 step process using Anthranilic acid and Benzoyl chloride as starting materials. The melting points were found for the synthesized compounds and are uncorrected. The purity of the synthesized compounds were analyzed by Thin Layer Chromatography method. The structures of the synthesized compounds has been elucidated by Infrared, Nuclear magnetic resonance spectroscopy & Mass spectroscopy. The anti-cancer activity of the synthesized compounds (10mg/kg) were screened by using Dalton’s Lymphoma Ascites (DLA) cells in albino mice against the standard drug 5-FU (20mg/kg). The results obtained showed that the attachments of piperazine, Dicyclohexylamine,Morpholine,aniline,4-aminophenol,Indole moieties to the quinazolin-4(3H)-one ring exhibited significant anti-cancer activity. The anti-inflammatory activity of the synthesized compounds (10mg/kg) were screened by carrageenan induced paw edema method in albino rats against the standard drug Diclofenac sodium (10mg/kg). From the obtained results quinazolin-4(3H)-one ring having substitutions like Indole, Dicyclohexylamine, Benzimidazole, 4-aminophenol, aniline, PABA showed significant anti-inflammatory activity. Future investigations can be made to study its pharmacokinetic parameters, potency, efficacy, drug interactions, side effects of the titled compounds in order to bring out the novel quinazolin-4(3H)-one derivatives as a successful drug molecules. Extended studies can be made to broaden the therapeutic utility of the synthesized compounds such as anti-microbial, anti-malarial, antituberculosis, anti-HIV, anti-parkinsonism, anti-histaminic, local anaesthetic, anti-hypertensive and anti-viral activities.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Molecular Modelling; Synthesis; Characterization; Biological Evaluation; Amino Quinazolin |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 12 Jul 2017 06:18 |
| Last Modified: | 12 Oct 2017 03:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1515 |
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