Parvathi Devi, R (2012) Molecular Design, Synthesis, Characterization & In-Vitro Biological Evaluation of Some Substituted Quinoxaline-2(1h) One Derivatives. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
Medicinal Chemistry is a science whose roots lie in all branches of Chemistry and Biology. The practice of Medicinal Chemistry is devoted to the discovery and development of new agents for treating diseases. Medicinal Chemistry occupies a strategic position at the interface of Chemistry and Biology. As per invitro anti inflammatory assay (protein denaturation). The synthesized compound (7,9,10 ) shows significant anti inflammatory activity.The result from present study shows that introducing thiazolidinone nucleus to the quinoxaline-2-one and aromatic ring having methoxy group increases the activity . A further study (Toxicological study and in vivo Pharmacological screening) on this compounds suggests attractive starting point to find new lead compounds with potential improvements, ultimate use as pain reliever. 10. The synthesized compounds were screened to obtain Zone of inhibition. The antimicrobial activities of the compounds were compared with standard drug Ciprofloxacin, among the synthesized derivatives compound 10 were found to be good in antimicrobial activity. Thus based on the above observations we can conclude that only at high concentrations, the compound(6,7,8,9) may act as antibacterial activity as compared to the standard drug the entire study reveals that the compounds will be modified structurally based on substitution and the difference in activity can also determined.By incorporating many more ring system to the quinoxaline nucleus could lead to more potent and highly active compound.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Molecular Design; Synthesis; Characterization; In-Vitro Biological Evaluation; Substituted Quinoxalin; One Derivatives |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 12 Jul 2017 06:12 |
| Last Modified: | 12 Oct 2017 03:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1511 |
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