Naina, Emmanuel (2010) Evaluation of the bacteriological and clinical profile of chronic pharyngitis with emphasis on studying the potential role of atypical pathogens as etiological agents. Masters thesis, Christian Medical College, Vellore.
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Abstract
Objectives/Hypothesis: To study the clinical and microbiological profile of patients with chronic pharyngitis with special emphasis on role of atypical organisms such as Chlamydia pneumoniae,Mycoplasma pneumoniae and Fusobacterium necrophorum. Study design: A prospective case control study. Methods: 344 patients with chronic pharyngitis were clinically evaluated to exclude non infectious causes of pharyngitis. Of these, 71 patients in whom comprehensive otorhinolaryngological examination did not elicit any factor contributing to the chronic pharyngeal complaint were recruited as cases and healthy asymptomatic adults were taken in the control arm. Both groups underwent throat swab for aerobic and anaerobic culture and ELISA to detect IgA antibodies against Chlamydia pneumoniae and mycoplasma pneumoniae. Results: Thirty-five of the 71 patients (49.3%) and 16 of the 71 control subjects (22.5%) were found to be seropositive for Chlamydia pneumoniae. Anaerobic organisms including Fusobacterium spp. were found to be significantly lower in cases as compared to controsl (p =0.041).There was no significant difference between cases and controls in aerobic culture growth and seropositivity to Mycoplasma pneumoniae. Patients with chronic pharyngitis were found to have a significantly higher rate of C.pneumoniae seropositivity than the control group (p = 0.001). Conclusions: Infection with Chlamydia pneumoniae seems to be a significant etiological factor for chronic pharyngitis.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | chronic pharyngitis; infection; chlamydia pneumonia; mycoplasma pneumonia; atypical pathogens |
| Subjects: | MEDICAL > Otolaryngology |
| Depositing User: | Devi S |
| Date Deposited: | 12 Jul 2017 06:05 |
| Last Modified: | 12 Jul 2017 06:05 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1509 |
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