Guptha Juluri, S M (2012) Design and Synthesis of Some Novel Michael addition Derivatives of 2,4- Disubstituted Oxazol-5(4H)- One as Possible Anti-Diabetic, Anti-Oxidant and Anti-Fungal Agents. Masters thesis, KMCH College of Pharmacy, Coiimbatore.
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Abstract
Diabetes mellitus (DM) is a major degenerative disease in the world today. Several epidemiological and clinical studies indicate a direct relationship between hyperglycemia and long-term complications such as retinopathy, nephropathy, neuropathy and various fungal infections etc. This study was undertaken to evaluate the activity of some Novel Michael Addition derivatives of 2,4-disubstituted Oxazol-5(4H)-one derivatives against Diabetes and its complications by using in vitro enzyme inhibition technique. These derivatives showed considerable biological efficacy when compared to pioglitazone, a potent and well known anti diabetic agent as a reference drug. All the compounds were effective, amongst them di methyl amino benzaldehyde (A6 and B7) and acetaldehyde derivatives (A1 and B1) shown more prominent activity.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Oxazolone scaffold; Retinopathy; Neuropathy; Nephropathy |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 12 Jul 2017 05:42 |
| Last Modified: | 13 Oct 2017 00:14 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1500 |
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