Suresh Kumar, K (2012) Design, Synthesis and Anticancer Activity of Noval Piperidine Hydroxamate as HDAC Inhibitors. Masters thesis, KMCH College of Pharmacy, Coiimbatore.
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Abstract
Thirteen compounds were synthesized with piperidine in linker region and hydroxamate as Zinc Binding Group (ZBG). They were screened against (HeLa) human cervical cancer cell-line. Of those, compound 3l (N-hydroxy-1-{[(2E)-2-(2-hydroxybenzylidene) hydrazinyl] carbonothioyl} piperidine-4-carboxamide) was found a lead compound with promising IC50 value of 5.83nM. Further the lead compound would be evaluated against a panel of cancer cell lines and establish its possible mechanism through enzyme inhibition assay.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Design; Synthesis; Anticancer; Noval Piperidine Hydroxamate;s HDAC Inhibitors |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 12 Jul 2017 05:13 |
| Last Modified: | 12 Oct 2017 02:58 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1491 |
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