Umamaheswari, V (2010) Synthesis, Characterization of Some Novel 2-Butyl-3-Substituted Quinazolin-4(3h)-Ones and Evaluation of Anti Convulsant and Analgesic Activities. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
|
Text
Umamaheswari V.pdf Download (1MB) | Preview |
Abstract
Drug discovery has its beginning in the root of mankind. Medicinal chemistry is a science whose roots lie in all branches of chemistry and biology. The practice of medicinal chemistry is devoted to the discovery and development of new agents for treating disease2. The recent advancement like drug designing, combinatorial chemistry, molecular biology and genetic engineering make interesting the medicinal chemistry approach Novel 2-(n-butyl)-3-substituted amino Quinazolin-4(3H)-ones were synthesized by a 3step process using Anthranilic acid and Pentanoic anhydride as starting materials. • The Melting points were found for the synthesized compounds and are uncorrected. The purity of the synthesized compounds were analysed by Thin Layer Chromatography methods. The structures of the synthesized compounds has been elucidated by Infrared and Nuclear Magnetic Resonance Spectroscopy. The anticonvulsant activity of the synthesized compounds (5mg/kg) were screened by Supra Maximal Electrical Shock method in Albino Rats against the standard drug Phenytoin (25mg/kg) The result obtained showed that the attachments of diethyl amine,4-bromo aniline, 4-nitro aniline, P-Amino benzoic Acid, Sulphanilamide and Indole moieties to the Quinazolin- 4(3H)-one ring exhibited significant Anticonvulsant activity. Based on the results, the attachment of dimethyl amine, benztriazole to Quinazolin- 4(3H)-one shown to have moderate Anticonvulsant activity while diphenyl amine, aniline substituted Quinazolin-4(3H)-one shown to have less Anticonvulsant activity comparatively. The analgesic activity of the synthesized compounds (5mg/kg) were screened by Acetic Acid Induced Writhing method in Albino rats against the standard drug Diclofenac sodium(25mg/kg)
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Synthesis; Characterization; Novel; Butyl; Substituted Quinazolin; Evaluation; Anti Convulsant; Analgesic Activities |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 12 Jul 2017 05:01 |
| Last Modified: | 12 Oct 2017 02:57 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1489 |
Actions (login required)
 |
View Item |
