Prevalence of Dermatophytosis in a Tertiary Care Centre.

Sudha, M (2009) Prevalence of Dermatophytosis in a Tertiary Care Centre. Masters thesis, Madurai Medical College, Madurai.

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Abstract

INTRODUCTION: Fungi are widely found in the environment and most of Them are harmless commensals, contaminants or non pathogenic Agents. There are atleast 100,000 named species of fungi of which Less than 500 are associated with human and animal disease.4 The incidence of mycotic infections is increasing. A major Contributor to the emergence of fungal infections is the increasing Number of immunocompromised individuals especially acquired Immuno deficiency syndrome. The fungi are now recognized as Significant cause of morbidity and mortality among humans. They Have emerged as an important etiological agent of opportunistic Infections.4 Fungal infections are broadly classified as superficial, Subcutaneous, and systemic mycosis. Superficial or cutaneous Mycosis are caused by fungi that infect only the superficial Keratinized tissue (skin, hair and nails). The most important of these Are dermatophytes.28 Skin infections due to dermatophytes have become a Significant health problem affecting children, adolescents and Adults. Accurate diagnosis is important to initiate appropriate Treatment and also essential for epidemiological purposes. In the Background of immunosuppression, detection of these agents Becomes mandatory for the effective management of cutaneous Mycosis. The dermatophytes are hyaline septate molds with more Than 100 species described. Nearly 40 % of these are associated With human disease. According to emmon’s morphological Classification, the dermatophytes are classified into three Anamorphic genera -trichophyton, microsporum and Epidermophyton based on conidial morphology. 1 Some species of dermatophytes are endemic in certain Parts of the world and have a limited geographic distribution. T.soudanense, t.gourvilii and t.yaoundii are restricted to central And west africa. M.ferrugineum predominates in japan. T.concentricum is confined to islands in the south pacific. The Increasing mobility of the world’s population is disrupting several Epidemiological patterns. Some dermatophytes like e.floccosum, T.rubrum and t.tonsurans are globally distributed.4 the Dermatophytes manifest as infections of keratinized tissue like skin, Hair, nails etc., of humans and animals. Dermatophyte infections can be treated effectively if timely And proper diagnosis is made. The different syndromes of Ringworm infections require different treatment regimens. Generally topical therapies are used for localized or mild infections And oral antifungals for more extensive infections in addition to Topical therapy. The newer azoles such as fluconazole or Itraconazole and terbinafine are now the preferred oral drugs to Griseofulvin for extensive or severe dermatophytosis. Although Griseofulvin is cheaper it is less effective. Though various topical and systemic agents are available For the treatment of dermatophytosis, chronic dermatophytosis is Commonly seen. Chronic dermatophytosis is a refractory condition Which runs a course of one year with remissions and exacerbations. Resistance to antifungals have been reported with Dermatophyte infections especially in nail infections. The resistance Pattern can be studied using various methods like macrodilution, Microdilution, disc diffusion etc., Though various indian and international studies on Epidemiology of dermatophytes are available, no such study has Been carried out in madurai. Since government rajaji hospital, (grh) madurai is the largest tertiary care hospital affiliated to Madurai medical college catering to the needs of lakhs of people From the southern districts of tamilnadu, the present study was Carried out among patients attending grh and the data were Analysed with reference to objectives. Efforts have been made to compare the prevalence of Dermatophytosis in non hiv and in hiv patients. In addition, Antifungal susceptibility tests for selected isolates to fluconazole And terbinafine was performed.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Prevalence ; Dermatophytosis ; Tertiary Care Centre.
Subjects: MEDICAL > Microbiology
Depositing User: Subramani R
Date Deposited: 19 Aug 2017 02:24
Last Modified: 19 Aug 2017 02:24
URI: http://repository-tnmgrmu.ac.in/id/eprint/1476

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