Platelet Alloantibody Specificities in Multiply Transfused Patients.

Madhan Kumar, B K (2008) Platelet Alloantibody Specificities in Multiply Transfused Patients. Masters thesis, The Tamil Nadu Dr. M.G.R. Medical University, Chennai.


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Transfusion plays an important role in the management of patients with hematological malignancies and disorders. Patients during the induction chemotherapy may need multiple transfusion of platelets and red cells and may develop refractoriness; platelet count increment deteriorate even after adequate dose of platelets are transfused. Although several studies reported non-immunological factors like fever, Splenomegaly, septicemia and severe bleeding are responsible for refractoriness in some patients, no specific reasons can be found. This raises the suspicion of platelet antibodies for the cause of refractoriness. Till now in many studies, the presence of HLA and platelet specific antibodies were found to be between 10%-60%in the patients who were treated with multiple transfusions. Our results concluded that multiple random donor blood and platelet transfusion are able to induce antibodies against HLA class 1 antigens and epitopes on GP iib/iiia. There was no relationship between the number of units transfused and the antibodies formation. Women with single pregnancy history were identified as high responder group for alloimmunization. Our results show AML are frequently immunized than ALL patients. Keeping in view the alloimmunization, leukoreduced irradiated single donor platelets and blood components should be transfused for the treatment of hematological and oncological patients. Till now, non-leukoreduced components are used in most of the centers in India due to cost of leukoreduction. Testing for the presence of platelet antibodies and transfusion of compatible platelets shall be important mode of management and prevention of platelet refractoriness in India.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Platelet Alloantibody; Multiply Transfused Patients
Subjects: MEDICAL > Immunohaematology Blood Transfusion
Depositing User: Kambaraman B
Date Deposited: 21 Jun 2017 05:51
Last Modified: 16 Jun 2019 02:23

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