Karthikeyan, K S (2015) To Study the Immunohistochemical expression of BRCA 1 in breast cancer and to assess its association with expression of ER, PR and HER 2 receptors. Masters thesis, PSG Institute of Medical Sciences & Research, Coimbatore.
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Abstract
Invasive breast cancer in women is a disease of global concern. Overall,invasive breast carcinoma is the second most common malignancy next to lung cancer. BRCA 1 gene mutation is one of the commonest causes of hereditary type breast carcinoma. BRCA 1 mutation if detected earlier, would improve the prognosis of patient in terms of devising a treatment plan that involves prophylactic mastectomy as these patients are prone to develop carcinoma sooner or later. Therefore mutational studies might help in reducing the rate of incidence of breast carcinoma.Therefore we propose to study the prevalence of BRCA 1 mutation in breast carcinoma by Immunohistochemical study, its association with various phenotypic features and hormonal receptors This is a retrospective study. Cases reported as carcinoma breast were retrieved from the archives of department of pathology, between the years 2012 to 2015. H&E, IHC staining with ER, PR,HER 2 is done for the 42 selected cases and correlated with each other.Finally our study on breast carcinoma specimen revealed the incidence is around 3.1% of breast cancer among women in our institute. Majority of which occurs in the mean age group of 50.5 years. We infer that BRCA 1 mutation was seen most in grade 3 / high grade tumors. BRCA 1 mutation was also seen in hormone receptor negative cases, in particular estrogen receptors. The limitations of our study include small sample size. A larger prospective study on the utility of BRCA 1 immunohistochemistry is essential to prove the benefits of this mutation analysis for routine treatment and prognostic reasons.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Breast carcinoma; BRCA 1 ; ER ; PR ; HER 2 ; Immunohistochemistry. |
| Subjects: | MEDICAL > Pathology |
| Depositing User: | Laksham S |
| Date Deposited: | 11 Jul 2017 11:22 |
| Last Modified: | 09 Dec 2018 05:15 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1457 |
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