Vaseela Banu, A (2016) Vitamin D deficiency and its association with development of preeclampsia in primigravida. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION: Hypertension represents the most common medical complication of pregnancy affecting around 10% of women. It is a leading cause of maternal and perinatal morbidity. Hence it is important to screen for development of hypertension in pregnancy and prevent the complications. Abnormal placentation and impaired trophoblastic invasion is the trigerring factor. Vitamin ‘D’ has immunomodulatory property on placental tissue and its deficiency plays a important role in the pathogenesis of pre eclampsia. In normal pregnancy there is a increase in cardiac output and the systemic vascular resistance decreases due to peripheral vasodilation. These changes are mediated by prostacyclin, nitric oxide and progesterone. Diastolic blood pressure drops more than systolic, beginning around 8-10 weeks and reaches a nadir by 22-24 weeks and attains pre pregnancy level by term. Immediately after delivery, BP falls and then rises transiently for first few days due to vasomotor instability. OBJECTIVE: To study the association between vitamin D deficiency and development of preeclampsia in primigravida. DESIGN: Randomised prospective study. SETTING: Institute of social obstetrics Kasturba Gandhi Hospital. POPULATION: Women attending antenatal clinic in the hospital.( n=200) METHOD: To measure vitamin D (25 hydroxy vitamin D) from 12 TO 20 weeks of gestation. RESULTS: In vitamin D deficient group (< 12ng/ml), 12 patients( 44.4%) developed preeclampsia and one (2.0%) developed GHT. [p value < 0.0001]. In vitamin D insufficient group(12 to 30 ng/ml) 15 patients (55.6%) developed preeclampsia and 46 (93.9%) patients developed GHT.[p value < 0.0001]. In vitamin D sufficient group (>30ng/ml), 2 patients (4.1%) developed GHT. CONCLUSION: From this study it is concluded that Vitamin D deficiency has a significant association with development of preeclampsia and GHT.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Vitamin D, Preeclampsia, Gestational hypertension (GHT). |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 01 Apr 2021 01:20 |
| Last Modified: | 01 Apr 2021 01:20 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14530 |
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