Nanitha Lakshmi, K (2020) Evaluation of Oxidative Stress Biomarker and Psychometric analysis in Oral Lichen Planus: A Case-control study. Masters thesis, Vivekanandha Dental College for Women, Tiruchengode.
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Abstract
Lichen Planus is a chronic inflammatory condition that may affect the skin, scalp, nails, oral mucous membrane. It particularly involves buccal mucosa where it can present as a spectrum of disease variants. The etiopathogenesis of OLP appears to be complex & remains unknown in reports of its interactions with environmental, genetic and lifestyle factors. There is compelling evidence that oxidative stress drives the production of oxidation products, such as Super Oxide Dismutase, which may be critical for the induction of some inflammatory skin diseases. SOD constitutes the first line of defence against oxygen-derived free radicals, SOD catalyzes the conversion of [O-] to H2O2, which may participate in cell signaling. OLP is often referred to as stress associated ulcerations of the oral mucosa and research to date hints on a psychosomatic component in the etiology and progression of OLP. Hospital anxiety and depression (HAD) scale was designed for assessment of anxiety & depression in hospital outpatients in an adult population. The following inferences were made in the present study: ◆ The mean anxiety levels were higher among cases when compared to controls, the difference between the groups is highly significant (p value = 0.001). ◆ The mean depression levels were higher among cases when compared to controls, the difference between the groups is highly significant (p value = 0.000). ◆ The mean salivary SOD levels were higher among cases when compared to controls, the difference between the groups is highly significant (p value = 0.001). ◆ The mean serum levels were higher among cases when compared to controls, the difference between the groups is highly significant (p value = 0.004). In the future, researches should be done by considering larger sample size, follow-up of patients was not done in this study, Further research by including the follow-up of salivary SOD status can yield better understanding on the salivary biomarker level in premalignant and malignant states. CONCLUSION: This study was carried out to assess the validity of salivary biomarker, Superoxide Dismutase for the detection of oxidative stress in oral lichen planus. The results suggest that there is a significant difference in mean salivary SOD values among the 2 groups. The salivary SOD is significantly expressed in the individuals with oral lichen planus. Therefore, salivary SOD can be used as a biomarker for the detection of oral lichen planus. The detection of this enzyme can serve a potent diagnostic aid for the early detection of oxidative stress occurring in the oral cavity. Further studies are required to validate the results and use the test in the future.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 241727501 |
| Uncontrolled Keywords: | Oral Lichen Planus, Hospital anxiety and depression (HAD) scale, Oxidative Stress Biomarker, Super Oxide Dismutase. |
| Subjects: | DENTAL > Oral Medicine and Radiology |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Feb 2021 16:18 |
| Last Modified: | 25 Feb 2021 16:18 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14525 |
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