Sam Ponraj Davidson, S (2020) Assessment of Brush Biopsy Findings and Salivary LDH Levels in Oral Mucosal Lesions of Tobacco Users. Masters thesis, K.S.R. Institute of Dental Science and Research, Tiruchengode.
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Abstract
INTRODUCTION: The Oral Brush Cytology has been developed to improve efficacy of conventional cytology and salivary LDH which is a cytoplasmic enzyme has been widely used as a marker for diagnosing various diseases. The purpose of the study is to evaluate and compare the brush biopsy findings with the corresponding salivary LDH levels for the early diagnosis of premalignant and malignant lesions of the oral cavity. MATERIALS AND METHODS: A total of 80 patients with deleterious habits with tobacco related lesions were screened and included in the study. For each patient saliva sample was collected and brush biopsy was done and smears were prepared. Collected saliva samples were analyzed for salivary LDH levels and prepared smears were analyzed for dysplastic changes and statistical analysis was made. RESULTS: Out of 80 sapmples, 30 were leukoplakia, 45 were tobacco pouch keratosis and 5 were oral cancer and 13 samples showed positive dysplastic changes, 26 samples showed atypical dysplastic changes and 41 samples showed no signs of dysplastic changes and concluded as negative. On comparing the results of brush biopsy findings and salivary LDH levels the mean salivary LDH value for the samples with positive dysplasia was 103.615, the mean salivary LDH value for the samples with atypical dysplasia was 65.449 and the mean salivary LDH value for the samples with negative dysplasia was 48.721 and the P-value was statistically significant. CONCLUSION: The role of brush biopsy in detection of oral cancer is possible even at early stage of the lesion. When comparing with other noninvasive techniques, brush biopsy showed increased sensitivity and specificity in detecting premalignant lesions and Salivary LDH levels which can be used as a diagnostic biomarker and its detection can serve as a potent diagnostic aid.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 241727403 |
| Uncontrolled Keywords: | Brush Biopsy Findings, Salivary LDH Levels, Oral Mucosal Lesions, Tobacco Users. |
| Subjects: | DENTAL > Oral Medicine and Radiology |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Feb 2021 15:01 |
| Last Modified: | 25 Feb 2021 15:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14522 |
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