Jayanthiswari, K (2020) Serum Lipid Profile and C-Reactive Protein as a Prognostic Marker in Oral Submucous Fibrosis. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.
|
Text
242902020jayanthiswari.pdf Download (7MB) | Preview |
Abstract
BACKGROUND: Oral submucous fibrosis is a chronic, premalignant condition of the oral mucosa, affecting millions of people globally and it is one of the precancerous conditions most prevalent in India. Various biochemical markers are available for detection of potentially malignant disorders. One such important marker is serum lipid profile. Previously published studies have evaluated the serum lipid profile and C-reactive protein in various potentially malignant disorders and oral squamous cell carcinoma, but to our knowledge no studies are available comparing the pre-treatment and post-treatment lipid profile and C-reactive protein values in oral potentially malignant disorders, so that their real prognostic value can be assessed. AIM OF THE STUDY: The aim of the present study is to evaluate the serum lipid profile and C - reactive protein as a prognostic marker in OSF patients. Objectives: To evaluate the serum lipid profile including (i) Total cholesterol, (ii) LDL cholesterol, (iii) HDL cholesterol, (iv) VLDL cholesterol and (v) triglycerides, (vi) C-reactive protein in patients with various stages of OSF. To correlate alterations in serum lipid profile and C-reactive protein pre and post-treatment. To correlate the alterations in serum lipid profile and C-reactive protein with improvement in symptoms post-treatment. METHODS: A total of 30 clinically diagnosed OSF patients of either gender in the age group of 20 – 50 years were selected. A complete history taking followed by a thorough oral examination was done to all patients. Burning sensation of the patient was assessed by using visual analog scale and mouth opening measured using caliper and measuring scale. These 30 patients were subdivided into 4 stages according to Khanna et.al staging system of OSF. 5 ml blood sample was collected before treatment and after 6 weeks of treatment for estimation of serum lipid profile & CRP. RESULTS: The mean age of the patient was 30.73 ± 7.5, with a male predominance (96.6%). The mean increase in mouth opening post treatment was 6.03 ± 1.7. All patients (100%) in Grade 1 & Grade 2 after completion of the treatment regimen, reported a complete relief from pain/burning sensation. The mean values of serum lipid profile (Total cholesterol, Triglycerides, HDL, LDL, VLDL) were decreased among OSF patients and the difference between pre and post treatment were statistically significant. The comparison of mean values of the pre-treatment and post treatment CRP level of the study subjects among OSF patients were found to be statistically significant (p=0.022). The mean CRP levels decreased by 0.55 ± 1.2 post treatment. CONCLUSION: Hence, pre-treatment and post treatment serum lipid profile and CRP levels contributes to be of prognostic value in OSF.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Oral Submucous Fibrosis, Lipid profile, C - reactive protein. |
| Subjects: | DENTAL > Oral Medicine and Radiology |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Feb 2021 02:29 |
| Last Modified: | 25 Feb 2021 16:24 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14511 |
Actions (login required)
 |
View Item |
