Expression of EpCAM in Oral Precancerous Lesion and in Oral Squamous Cell Carcinoma: An Immunohistochemical study

Rajarajeswari, V (2020) Expression of EpCAM in Oral Precancerous Lesion and in Oral Squamous Cell Carcinoma: An Immunohistochemical study. Masters thesis, Madha Dental College and Hospital, Chennai.


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INTRODUCTION: Epithelial cell adhesion molecule is a type I transmembrane calcium-independent homophilic cell adhesion molecule belongs to the special CAM family. It is one of the first tumour-associated antigens identified. It is normally expressed in the basolateral membrane layer of majority of epithelial cells except in the adult squamous epithelium. EpCAM plays an important role in cell adhesion, signal transduction and cell cycle regulation. It was reckoned to be a promoter of proliferation, migration, invasion and potential antagonist of differentiation. Its expression is frequently correlates with more aggressive tumour behavior. AIM AND OBJECTIVE: To analyze the immunohistochemical expression pattern of EpCAM in OSCC and in Oral Potentially Malignant Disorders and its use in assessing the prognosis of oral squamous cell carcinoma and to predict the malignant transformation in dysplasia cases. MATERIALS AND METHODS: In our study total sample size of 48, containing 24 OSCC cases and 24 dysplasia cases (clinically Leukoplakia) along with 5 normal oral mucosa tissues were used. The tissues were retrieved from the department of Oral Pathology & Microbiology and selected after re-confirmation of the diagnosis by histopathological examination. Immunohistochemistry was done by using the PolyExcel HRP/DAB system and the expression was graded in terms of proportion and intensity and statistically analyzed. RESULTS: There was a significant expression of EpCAM in OSCC cases and also in some dysplasia cases. No expression of EpCAM is seen in normal mucosal tissues and the p-value is significant. CONCLUSION: The findings of the present study revealed that the increased EpCAM expression in oral squamous cell carcinoma cases indicate the poor prognosis. The expression in Dysplasia cases indicates the increased potential towards malignant transformation. EpCAM may serves as a potential biomarker of prognostic significance, so it could be used to identify the patients at high risk and to predict their survival.

Item Type: Thesis (Masters)
Additional Information: 241721502
Uncontrolled Keywords: EpCAM, Immunohistochemistry, Oral squamous cell carcinoma, Dysplasia.
Subjects: DENTAL > Oral Pathology and Microbiology
Depositing User: Subramani R
Date Deposited: 24 Feb 2021 17:05
Last Modified: 24 Feb 2021 17:05

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