Vinoth, K (2020) Immmunohistochemical Expression of Survivin in Different Grades of Oral Squamous Cell Carcinoma. Masters thesis, Adhiparasakthi Dental College and Hospital, Melmaruvathur.
|
Text
242619720vinoth.pdf Download (2MB) | Preview |
Abstract
BACKGROUND: Oral squamous cell carcinoma (OSCC) indicates a heterogenous group of different epithelial malignancies that arise from uncontrol led growth of epithelial cells. The poor prognosis of oral cancer is due to several reasons such as late stage diagnosis, low response to current therapeutic strategies, primary site recurrence, high rate of metastasis to regional lymph nodes etc. which has strongly recommended the need to improve the diagnostic capabilities. Assessing the tumor behaviour at the molecular level will help in initiating appropriate management there by reduc ing the morbidity associated with malignancy. Survivin is an inhibitor of apoptotic protein that has multiple pathways regarding the regulation of cell division, modulation of apoptotic and non apoptotic cell death, the maintenance of cell proliferation an d resistance to various anticancer therapies. AIM OF THE STUDY: To evaluate the immunohistochemical expression of survivin in different grades of oral squamous cell carcinoma. MATERIALS AND METHODS: A total of 40 samples were examined for the immunohistochemical expression of survivin. The control group included 10 formalin fixed paraffin embedded tissue blocks of normal oral mucosa. The study group included 30 cases of formalin fixed paraffin embedded tissue blocks of oral squamous cell carcinoma (10 cases of well differentiated, 10 cases of moderately differentiated and 10 cases of poorly differentiated squamous cell carcinoma). Serial sections of 3micron thickness were made from each sample and stained with survivin antibody. The intensity of staining and area of staining for survivin was assessed and scored. The data obtained were statistically analyzed. RESULTS: Comparison of Intensity of Staining of Survivin showed a significant statistical difference between normal oral mucosa and oral squamous cell carcinoma. Comparison of Area of Staining of Survivin also showed a significant statistical difference between normal oral mucosa and oral squamous cell carcinoma. On comparing the staining intensity of survivin between the different grades of oral squamous cell carcinoma, there was a significant statistical difference. Similarly, on comparing the area of staining of survivin between the different grades of oral squamous cell carcinoma, there was again a significant statistical difference. CONCLUSION: Based on the present study, we conclude that survivin can be used as an important diagnostic and prognostic marker in future for cancer therapy.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 241721402 |
| Uncontrolled Keywords: | Squamous cell carcinoma, Immunohistochemistry, Survivin. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Subramani R |
| Date Deposited: | 24 Feb 2021 16:40 |
| Last Modified: | 26 Feb 2021 01:31 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14483 |
Actions (login required)
 |
View Item |
