Hariganesh, P (2020) Immunohistochemical Expression of MUC 1 Mucin in Different Grades of Oral Squamous Cell Carcinoma. Masters thesis, Adhiparasakthi Dental College and Hospital, Melmaruvathur.
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Abstract
AIM OF THE STUDY: To evaluate the expression of MUC1 Mucin in different grades of Oral Squamous Cell Carcinoma using ImunoHistoChemistry. MATERIALS AND METHODS: A total of 40 samples were examined for the Immunohistochemical expression of MUC1 Mucin. The study group includes 40 cases of formalin fixed paraffin embedded tissue blocks of oral squamous cell carcinoma (10 cases of well differentiated OSCC,10 case of moderately differentiated OSCC, 10 cases of Poorly differentiated OSCC and 10 cases of Normal Oral Mucosa- control group). 3 μ thickness sections were made from each sample and stained with MUC1 Mucin antibody. The intensi ty and area of staining were assessed and scored. The data obtained w a s statistically analyzed using SPSS software. RESULTS: There was a significant statist ical difference in the intensity of staining of MUC 1 Mucin between normal oral mucosa and oral squamous cell carcinoma. There was also a significant statistical difference in the area of staining of MUC 1 Mucin between normal oral mucosa and oral squamous cell carcinoma. When comparing the staining intensity of MUC 1 Mucin between the different grades of oral squamous cell carcinoma, there was a significant difference statistically. On comparison of area of staining of MUC 1 Mucin between the different grades of oral squamous cell carcinoma, there was again a significant difference statistically. High immunopositivity and strong staining intensity for MUC 1 Mucin was observed in well differentiated squamous cell carcinoma when compared to moderately differentiated squamous cell carcinoma and poorly differentiated squamous cell carcinoma. CONCLUSION: We conclude that MUC 1 Mucin biomarker can be used to detect higher grades of oral squamous cell carcinoma and hence, early detection in preventing invasion and metastasis.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 241721401 |
| Uncontrolled Keywords: | Squamous Cell Carcinoma, Immunohistochemistry, MUC 1 Mucin. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Subramani R |
| Date Deposited: | 24 Feb 2021 16:38 |
| Last Modified: | 26 Feb 2021 01:29 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14482 |
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