Ahila, T (2020) Evaluation of the Proliferative and Epithelial Mesenchymal Transition Characteristics in Oral Epithelial Dysplasia: A Case Control study. Masters thesis, Rajas Dental College and Hospital, Tirunelveli.
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Abstract
BACKGROUND: Abnormal proliferations, presence of cancer stem cells and epithelial mesenchymal transition have been hypothesized to play a vital role in the malignant transformation of dysplastic epithelium. The evaluation of these characteristics using molecular markers is been carried out in this study. AIM AND OBJECTIVE: To study and compare the expression of the proliferative marker Ki-67, cancer stem cell marker Oct-4, cell to cell adhesion molecule E-cadherin in oral epithelial dysplasia cases compared to controls. MATERIALS AND METHODS: Formalin fixed, paraffin embedded tissue sections of Oral epithelial dysplasia (n= 30) with equal representation from each grade which were histopathologicaly diagnosed were used in this study. Immunohistochemical analysis was performed with the antibodies against Ki-67, Oct-4 and E-cadherin and scoring was done based on the scoring criteria. RESULTS: Ki-67 expression between cases and controls was statistically significant, Oct-4 expression between cases and controls was not statistically significant and the expression of E-cadherin between cases and controls was statistically significant between cases and controls. CONCLUSION: The significant difference in the expression of the proliferative marker Ki67 and cell to cell adhesion molecule E cadherin between cases and controls suggest that these markers may play a vital role in transformation to malignancy.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 241721551 |
| Uncontrolled Keywords: | Ki67, Oct-4, E-cadherin, Oral epithelial dysplasia, Proliferation, Cancer stem cells, Epithelial mesenchymal transition. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Subramani R |
| Date Deposited: | 24 Feb 2021 16:32 |
| Last Modified: | 26 Feb 2021 01:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14480 |
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