Rameezuddin, T (2020) Comparison and Evaluation of Antimicrobial Efficacy of Curcumin Nanoparticle Hydrogel, Calcium Hydroxide Paste and 2% Chlorhexidine Gel as Intracanal Medicament against Enterococcus Faecalis: An In Vitro study. Masters thesis, Chettinad Dental College & Research Institute, Kanchipuram.
|
Text
242426720rameezuddin.pdf Download (4MB) | Preview |
Abstract
AIM OF THE STUDY: To compare and evaluate antibacterial efficacy of Curcumin nano particle hydrogel, Calcium Hydroxide paste and 2% Chlorhexidine gel as intracanal medicament against Enterococcus faecalis. MATERIALS AND METHODS: Curcumin nano particles were prepared by ball milling technique after which it was prepared into a gel form using Polyethyleneglycol. Minimum inhibitory concentration and Minimum bacterial concentration of the prepared gel was analyzed. Thus based on the results 3% Curcumin nano particle hydrogel was tested in present study. 120 freshly extracted premolar teeth were decoronated and biomechanical preparation was done following normal irrigation protocol and divided into following groups: Group I-Normal saline, Group II Calcium Hydroxide paste [Ca(OH)2], Group III Chlorhexidine gel (2% CHX ) and Group IV 3% Nano curcumin gel (3% N Cu gel). The samples were inoculated with E.faecalis (ATCC) for 2 weeks after which the medicaments were placed inside the canal (n=27). After treatment dentin shaving was collected at end of day 1, 3 and 7 at varying depth of 200μm and 400μm in BHI broth. Colony forming units was counted with the help of digital colony counter. RESULTS: Group 3 (2%CHX) was the most effective against E.faecalis on all days. Group 2 Ca(OH)2 and Group 4 (3%N Cu gel) was statistically significant from the control Group 1. Mean ± SD, bp<0.01; cp<0.001. On Day 1, significant difference is found between each group versus all other groups. On day 3, significant difference is found between each group versus all groups except between CHX and Nano Curcumin. On Day 7, significant difference is found between each group versus all the groups. CONCLUSION: Nano Curcumin gel can be used as an Intracanal medicament as the efficacy is almost similar to commercially available intracanal medicaments.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 241717752 |
| Uncontrolled Keywords: | Curcumin nano particle hydrogel, 2%Chlorhedine gel, Calcium Hydroxide paste, Intracanal medicaments and E.Faecalis. |
| Subjects: | DENTAL > Conservative Dentistry and Endodontics |
| Depositing User: | Subramani R |
| Date Deposited: | 22 Feb 2021 17:46 |
| Last Modified: | 22 Feb 2021 18:17 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14435 |
Actions (login required)
 |
View Item |
