Aneesha, S (2020) Comparison of Post Operative Healing of Extraction Socket With and Without Calcium Chloride Activated Platelet Rich Plasma: An In Vivo study. Masters thesis, Sree Mookambika Institute of Denal Sciences, Kulasekharam.
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Abstract
INTRODUCTION: Platelet-rich plasma (PRP) is a modern and potentially valuable adjunct in the area of oral and maxillofacial surgery. Platelet-rich plasma (PRP), an autologous concentrate of platelets in a proportionately meager quantity of plasma, expedites the delivery of growth factors in risen amounts to surgical sites to enhance wound healing. Platelets contain many growth factors. Some of the growth factors are, platelet-derived growth factor (PDGF) (including αα, αβ, and ββ isomers), transforming growth factor-β (TGF-β) (including β1 and β2 isomers), fibroblast growth factor, insulin-like growth factor-I (IGF-I), epithelial growth factor, vascular endothelial growth factor. The platelets also contain numerous other secretory proteins. AIM OF THE STUDY: The aim of the study is to evaluate clinically and radiographically, extraction socket healing using calcium chloride activated platelet rich plasma, compared to normal healing pattern. MATERIALS AND METHODS: Twenty-five patients needing bilateral similar tooth extractions were selected, and one side is taken as a control group and another side as the case group. PRP was prepared with blood drawn from individuals who came for extraction using standard double centrifugation technique, and 10% calcium chloride was added to activate PRP. The formed PRP gel was placed in the extraction socket of the case group and secured with sutures. An immediate digital radiograph was taken after extraction for both groups. Moreover, for soft tissue evaluation, patients reviewed at postoperative day 3rd, seventh, and 14th day and soft tissue healing index taken. For radiographic analysis, socket surface area and density were performed using a computer graphics software program. The clinical follow-up assessments were performed in the fourth week and third month, and the collected data were assessed using ANOVA and multiple comparison tests. RESULTS: Patients were aged between 18 to 32 (Mean age 24 years), including 17 females and 8 males. The mean soft tissue healing for the case group were 3.46, 4.42,5 at 3rd 7th and 14th day, respectively. The soft tissue healing was significantly higher among the test group as compared to the control group. The mean radiographic density in the case group was 57.752, 76.458 in 4th week and 3rd month, respectively. The mean bone density was significantly higher in the test group than the control group at all-time intervals. CONCLUSION: The study outcomes demonstrate that 10% calcium chloride activated PRP is biocompatible and accelerates socket wound healing after tooth extraction and increased bone density.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 241715251 |
| Uncontrolled Keywords: | Platelet Rich Plasma, 10% Calcium Chloride, Soft Tissue healing, Bone Density, Bilateral Extraction Socket. |
| Subjects: | DENTAL > Oral and Maxillofacial Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 22 Feb 2021 02:32 |
| Last Modified: | 22 Feb 2021 15:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14391 |
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