Jananippriya, V (2020) Evaluation of Salivary and Serum Periostin Levels in Periodontally Healthy and Diseased Individuals Before and After Non Surgical Periodontal Therapy. Masters thesis, Vivekanandha Dental College for Women, Tiruchengode.
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Abstract
BACKGROUND: Biomarker referred to a measurable indicator of some biological state or condition. It was also used to refer to a substance whose detection indicated the presence of disease activity. One such biomarker was periostin which was an extracellular matrix adhesion protein present in the connective tissue fibroblasts and had a decisive role in maintaining the periodontal integrity which was lost during the disease condition. AIM OF THE STUDY: The purpose of this study was to investigate the salivary and serum periostin levels in gingivitis and chronic periodontitis patients and to evaluate the effect of non surgical periodontal therapy. OBJECTIVES: 1. To compare the salivary and serum levels of periostin in periodontally healthy individuals, gingivitis and chronic periodontitis patients. 2. To evaluate the effect of non-surgical periodontal therapy on periostin levels in gingivitis and chronic periodontitis patients. 3. To assess whether periostin could be used as a marker for periodontal disease activity. MATERIALS AND METHODS: 60 individuals were enrolled in the study. Individuals were divided into three groups following clinical examinations: the periodontal– healthy group (n = 20), gingivitis group (n = 20) and chronic periodontitis group (n = 20). Salivary and serum samples were collected and periostin levels were determined using the enzyme-linked immunosorbent assay. RESULTS: The result from this study the salivary periostin levels were gradually decreased as the periodontal disease progress. So there was a negative correlation like periostin concentration is highest in healthy, low in gingivitis and lowest in periodontitis condition. After the non surgical periodontal therapy significant improvement was seen in the salivary periostin level from the baseline. The serum periostin level was increased in gingivitis and periodontitis when compared to healthy individuals. After the non surgical periodontal therapy, serum periostin concentration decreased with no significant difference between the groups. CONCLUSIONS: The periostin levels salivary and serum levels decreased proportionally with the progression and severity of periodontal disease, and negatively correlated with the clinical parameters.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 241713501 |
| Uncontrolled Keywords: | Salivary and Serum Periostin Levels, Periodontally Healthy and Diseased Individuals, Before and After Non Surgical Periodontal Therapy. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Feb 2021 16:46 |
| Last Modified: | 21 Feb 2021 16:46 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14368 |
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