Indumathi, P (2020) Estimation of Serum Albumin Levels in Chronic Generalised Periodontits, Localized Aggressive Periodontitis Patients and Compare it with Periodontally Healthy Individuals. Masters thesis, Adhiparasakthi Dental College and Hospital, Melmaruvathur.
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Abstract
BACKGROUND: Serum albumin is a negative acute phase protein, primarily synthesized by liver. Many factor affects the regulation of serum albumin levels. The primary ones involved are inflammation and malnutrition. Chronic disease which are associated with inflammation and the release of inflammatory cytokines such as interleukin -1, interleukin-6 and tumor necrosis factor α cause decrease in albumin. Periodontitis is a chronic inflammatory disease caused by bacterial infection of the supporting tissues around the teeth. A few studies have shown that serum albumin levels are reduced in patients with Generalised chronic Periodontitis. AIM OF THE STUDY: 1. To estimate and compare the serum albumin levels in chronic generalised and localized aggressive Periodontitis patients with that of Periodontally heal thy individuals. 2. To identify whether chronic generalised periodontitis and localized aggressive periodontitis have any effect on serum albumin levels compared to Periodontally healthy individuals. MATERIALS AND METHODS: Total number of 60 subjects were enrolled in this study with the age range of 18 -50 years. All subjects participating in the study were informed about the nature of the study and al l individuals signed in the written informed consent form. 60 subjects were divided into 3 groups. Group I- Periodontally healthy individual, Group II- Chronic generalised periodontitis, Group III - Localized aggressive periodontitis. Clinical parameters such as Gingiva l bleeding index (GI), Periodontal pocket depth (PPD), Clinical attachment level (CAL) and serum albumin level were evaluated between these three groups. RESULTS: Al l the clinical parameters shown to be increased significantly in patients with chronic generalised periodontitis (Group II) and localized aggressive periodontitis (Group III) when compared to periodontally heal thy individuals (Group I). There is a significant decrease in serum albumin level in patients with chronic generalised periodontitis (Group II) and localized aggressive periodontitis (Group III) when compared to periodontally healthy individuals (Group I). CONCLUSION: With the limitations of the present study it could be concluded that there is inverse relationship of serum albumin level and periodontal disease. So, serum albumin level can be used as a predictive marker for severity of periodontitis. Further randomized clinical trials and longitudinal evaluations in a larger population would be required to support the observation of the present study.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 241613452 |
| Uncontrolled Keywords: | Serum Albumin Levels, Chronic Generalised Periodontits, Localized Aggressive Periodontitis Patients, Periodontally Healthy Individuals. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Feb 2021 16:05 |
| Last Modified: | 21 Feb 2021 16:05 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14362 |
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