Vishnu Priya, R (2020) A Comparative Evaluation of Serum Leptin Level Before and After Phase I Periodontal Therapy in Aggressive Periodontitis. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.
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Abstract
BACKGROUND: Leptin, an adipocytokine with pro-inflammatory properties plays an important role in regulation of immunologic and inflammatory responses of the body. The role of non-surgical periodontal therapy (NSPT) in altering the leptin concentrations in serum of Aggressive periodontitis patients is yet to be ascertained. AIM OF THE STUDY: The aim of the present study is to assess and evaluate the concentration of leptin in serum before and after phase I periodontal therapy in aggressive periodontitis patients. MATERIALS AND METHOD: Level of serum leptin was determined in healthy subjects (control group, n=30) and patients with aggressive periodontitis (study group, n=30) and compared with clinical parameters like gingival bleeding index, plaque index, probing pocket depth and clinical attachment level before and after phase-I therapy. RESULTS: Clinical parameters and leptin level were increased in the serum of patients with aggressive periodontitis before phase I therapy compared to healthy subjects. Statistically significant (p < 0.01) reduction in clinical parameters and serum leptin level were seen after Phase-I therapy. CONCLUSION: These results suggest that periodontal inflammation may up-regulate serum leptin level and increase clinical parameter values in patients with aggressive periodontitis and phase I therapy was able to restore the serum leptin levels and clinical parameters.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 241713006 |
| Uncontrolled Keywords: | Serum Leptin, Aggressiveperiodontitis, Phase I therapy. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Feb 2021 14:21 |
| Last Modified: | 21 Feb 2021 14:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14351 |
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