Dasarathan, V (2020) Estimation of Serum Albumin Levels Before and After Phase I Periodontal Therapy in patients with Aggressive Periodontitis. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.
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Abstract
BACKGROUND: Periodontitis is an inflammatory disease of the supporting tissues of the teeth caused by bacterial infection, resulting in progressive destruction of the periodontal ligament and alveolar bone, possibly also tooth loss. Serum albumin is a negative acute phase protein and its concentration is associated with nutrition and inflammation; serum albumin levels might be the practical marker of general health status. AIM OF THE STUDY: The aim of this study is to evaluate the serum albumin levels in Aggressive Periodontitis before and after phase I periodontal therapy. MATERIALS AND METHODS: A total of 60 individuals of both genders with age range of 18 to 30 years, who were equally divided into two groups, one group with clinically healthy periodontium (Group I or control group) and another group with Aggressive periodontitis (Group II or Test group). Serum albumin concentration was estimated by bromocresol green albumin method at baseline for both group I and group II subjects, at 3 months after phase I periodontal therapy for group II subjects. Clinical parameters, including plaque index, gingival bleeding index, periodontal pocket depth and clinical attachment level, were assessed and at baseline for both group I and group II subjects, at 3 months after phase I periodontal therapy for group II subjects. RESULTS: The results showed serum albumin levels were significantly decreased in group II (Test group) at baseline when compared to group I (control group). The mean serum albumin level at baseline in group II (test group) is 4.126±0.241 and in group I (control group) is 4.810±0.147 with mean difference is 0.68 and P value <0.001, indicating difference between serum albumin levels in group I and group II were statistically significant. In group II (Test group) individuals serum albumin levels significantly improved after phase I periodontal therapy, the mean serum albumin level at baseline 4.126±0.241 and 3 months after phase I periodontal therapy 4.639±0.179, with mean difference -0.51 and P value <0.001, indicating difference were statistically significant. CONCLUSION: Within the limitations of the present study, it can be concluded that the serum albumin level is significantly decreased in aggressive periodontitis patients, compared to healthy controls, this suggest a statistically significant inverse relationship between the serum albumin concentration and periodontal disease. In aggressive periodontitis patients, after periodontal therapy serum albumin levels significantly improved. This suggests that periodontal disease severity might be monitored by the serum albumin levels and hence it can be used as a risk predictor for periodontal disease.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 241713001 |
| Uncontrolled Keywords: | Periodontitis, aggressive periodontitis, serum albumin, phase I periodontal therapy. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Feb 2021 14:02 |
| Last Modified: | 21 Feb 2021 14:02 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14347 |
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