Bacteriological Profile of Diabetic Foot Ulcers with special reference to HbA1C Levels.

Shahjahan, A (2013) Bacteriological Profile of Diabetic Foot Ulcers with special reference to HbA1C Levels. Masters thesis, Coimbatore Medical College, Coimbatore.


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BACKGROUND : Diabetes mellitus is a progressive disease, diabetic foot is the major complication of it, and eventually leads to development of gangrene and lower extremity amputation. This study has been carried out to detect the antibiotic sensitivity pattern of the isolates in relation to HbA1C levels. OBJECTIVES : To study the prevalence of diabetic foot ulcers in various age groups and gender. To isolate and identify the bacterial isolates causing diabetic foot infections. To analyze HbA1C levels in relation with Diabetic Foot Infections, bacteriological profile and antibiotic susceptibility pattern. MATERIALS AND METHOD : Pus and wound swabs were collected from around 100 diabetic patients with foot ulcer attending the Surgery Out-Patient Department of Coimbatore Medical College Hospital. The samples received in the Department of Microbiology were processed for aerobic culture and antibiotic sensitivity testing during the study period. Blood samples were collected to analyze the HbA1C levels. RESULTS : Of The 100 cases studied, most of the patients belonged to the 5th and 6th decades of life (37%) and (28%) respectively. Males were more affected compared to females with a ratio of 2.3:1. Maximum number of patients with Diabetic Foot Ulcers were seen in Wagner’s Grade II (40 nos), followed by 38 DFI patients in Wagner’s Grade III. Among Gram positive aerobes, Staphylococcus aureus was the predominant Isolate (18.4%). Among Gram negative aerobes, Proteus spp was the most common isolate (23.2%) followed by E.Coli 16.8% and Pseudomonas 16%. Acinetobacter species was the least common isolate (2.4%). While staphylococcus aureus was the most common among gram positive cocci, Proteus species was the most common isolate among the gram negative pathogens. CONCLUSION : Staphylococci and Proteus were the two most common isolates detected in diabetic foot infections. There was significant association between DFI and higher HbA1C Levels. But no correlation found between HbA1C levels and the polymicrobial nature of infection in DFI.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Bacteriological Profile ; Diabetic Foot Ulcers ; Special Reference ; Hba1c Levels.
Subjects: MEDICAL > Microbiology
Depositing User: Subramani R
Date Deposited: 14 Aug 2017 04:42
Last Modified: 14 Aug 2017 04:42

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