Shamrath Banu, C (2020) Lowering Platelet Count: A Prognostic Index in Preeclampsia. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION: Hypertensive disorders complicating pregnancy are common and form one of the deadly triad along with hemorrhage and infections that result in much of the maternal morbidity and mortality related to pregnancy. Hypertensive disorders complicate 5-10% of all pregnancies. Hematological abnormalities develop as a complication of preeclampsia. Out of all hematological changes that occur in preeclampsia. Severity of maternal thrombocytopenia is dependent on intensity of disease process. OBJECTIVE: my study is to know variation of platelet count in normal pregnancy and hypertensive disorders of pregnancy and correlate fetomaternal outcome with platelet count .Early detection of platelet count abnormalities in preeclampsia and eclampsia, which is a sign of worsening disease facilitates early detection of maternal and fetal complications, thereby its role as prognostic tool in management. MATERIALS AND METHODS: This is a prospective comparative study (cohort study) done in institute of social obstetrics and Kasturba Gandhi Hospital, Madras Medical College, Chennai from may 2018 to may 2019.The study included 150 women with gestational hypertension, pre eclampsia and eclampsia with varying severity and duration of pregnancy. The control group included 150 women with similar demographic features and no associated complications. Blood is taken every week from third trimester for study group and every 4 weeks for control group and platelet count was done. Platelet count and feto maternal outcome were compared between two groups. RESULTS: In this study prevalance of gestational hypertension is 60( 40%), mild preclampsia is 46.(30%). The prevalance of eclampsia and severe eclampsia were 10 (3%) and 34 (11%) respectively. The prevalance of HELLP was 14 (4.5%) and PPH was 21 (7%). The study proved that pre term delivery having significant association with severe eclampsia and eclampsia whereas in GHT and Mild pre eclampsia patients undergone term delivery. Most of the Mothers who had eclampsia and severe preeclampsia underwent caesarean section delivery. Majority of patients 79% with lesser than 1 to 1.5 lakh platelet counts had severe eclampsia. 56% of mild preeclampsia patients have platelet count 1.5 – 2 lakhs. In this study the mean platelet counts were 158000 ± 23301.03 in gestational hypertension, 188000 ± 39099.16 in mild preeclampsia, 95700 ± 19505.27 in eclampsia. CONCLUSION: With the present study results and interpretation,estimation of platelet count may be considered as an early, economical and rapid method of assessment of severity of hypertensive disorders of pregnancy cases. It can also be a useful screening test to assess the prognosis of the disease and outcome of pregnancy in pregnant women.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221716016 |
| Uncontrolled Keywords: | Lowering Platelet Count, Prognostic Index, Preeclampsia. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 16 Feb 2021 03:23 |
| Last Modified: | 16 Feb 2021 03:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14252 |
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