Atchaya, R (2020) Serum Selenium Levels in Thyroid Orbitopathy. Masters thesis, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai.
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Abstract
BACKGROUND: Selenium is an essential trace element and thyroid has the highest amount of selenium in our body per gram of tissue. It is necessary for the normal metabolism of the thyroid hormones and also possess antioxidant properties that protect the thyroid gland from autoimmunity. OBJECTIVE: This study was conducted to assess the correlation between the Serum selenium levels and severity and activity of thyroid orbitopathy and also to identify association between Serum selenium levels and thyrotropin receptor antibodies (TRAK) and Thyroid peroxidase antibodies (TPO). METHODS: Serum Selenium levels, TRAK, TPO antibody levels were measured in 38 patients. CAS is assessed in these patients and any statistical correlation between them is assessed. Any relation between demographic factors with these levels are assessed. RESULTS: The mean selenium concentration in our study group was found out to be 109.71 (27.25). 23-190 microgram/L was our laboratory normal range. Selenium levels of all patients falls within normal range. CAS was found to be linearly associated with Selenium values and Age. TRAK and TPO titres were not associated with Se. Inferior rectus is the found to be most enlarged of all the extraocular muscles. CONCLUSION: GO patients are at risk of a low Se status, yet the disease severity or activity does not seem to correlate with Se or TRAK or TPO antibody levels. However owning to the low patient volume and patients from same geographical area, these results neither support not discourage adjuvant Se supplementation attempts in TED patients. And further studies are essential to resolve this issue.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221713453 |
| Uncontrolled Keywords: | Selenium, Thyroid orbitopathy, TRAK, TPO antibodies, CAS. |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Feb 2021 15:55 |
| Last Modified: | 14 Feb 2021 15:55 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14204 |
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