Akila, T (2020) Correlation between Multi Modal Imaging and Visual Parameters in Retinitis Pigmentosa. Masters thesis, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai.
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Abstract
INTRODUCTION: Retinitis pigmentosa is a group of hereditary disorders of the photoreceptors and retinal pigment epithelium which gradually causes night blindness and progressive constriction of the visual field1,the prevalence of RP is 1 in 4000 individual. 2-4 It is a most common cause of visual loss in the world. The name retinitis pigmentosa was first described by Donder in 1857. Mode of inheritance of RP are autosomal dominant, autosomal recessive, X-linked recessive and sporadic. Prevalance of RP inheritance includes autosomal dominant is 20-25%, autosomal recessive is 15-20%, X-linked recessive is 10-15%, or sporadic/simplex traits is 30%. Rare inheritance of RP includes X-linked dominant, mitochondrial, and digenic. The age of onset and severity depending on the inheritance pattern. Autosomal dominant RP has the best prognosis, with good central vision even till the sixth decade. X -linked recessive has the least prognosis but severe visual impairments in affected male by the fourth decade. AIMS AND OBJECTIVES: This study was designed to study the correlation between structural and functional changes in the retina of retinitis pigmentosa patients. METHODOLOGY: The study was conducted between January 2018 and December 2018 on 53 patients with retinitis pigmentosa at Aravind Eye Hospital and Post Graduate Institute of Ophthalmology at Madurai. It is a cross sectional, observation study. All 104 eyes of RP patients underwent visual testing, IOP, anterior and posterior examination, structural changes measured on SD-OCT, OPTOS and functional changes measured by HFA, microperimetry. RESULTS: Among 104 eyes of 53 RP patients visual acuity was correlated with central macular thickness, AF ring of SD-OCT and OPTOS, perifoveal foveal thickness of inferior quadrant and IS/OS line. Visual field of HFA was moderately correlated with structural changes except choroidal thickness. Average threshold of microperimetry was moderately correlated with structural changes except choroidal thickness. This showed that function parameters were correlated with structural parameters. CONCLUSION: Multi-modal imaging to detect structural (OCT, OPTOS and reflectance imaging on Spectralis) and functional changes (microperimetry, static automated perimetry) in the retina may be useful for study RP patients.These structural and functional changes may also be useful for staging and selecting the patients for any future clinical trials that may begin, using newer modalities of therapy like immunomodulation, gene therapy, etc.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221713452 |
| Uncontrolled Keywords: | Correlation, Multi Modal Imaging, Visual Parameters, Retinitis Pigmentosa. |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Feb 2021 15:52 |
| Last Modified: | 14 Feb 2021 15:52 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14203 |
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