Aarthi Sudha, B (2020) Correlation of Corneal Ulcer Size and Depth Measurement by Slit Lamp Evaluation and Anterior Segment Optical Coherence Tomography: A Prospective Observational study. Masters thesis, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai.
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Abstract
INTRODUCTION: Corneal disease, including corneal infections and inflammatory diseases, is one of the major causes for blindness. Corneal ulceration is the loss of corneal epithelium with underlying stromal infiltration and suppuration associated with signs of inflammation with or without hypopyon. It can be caused by Bacteria, viruses, fungi and parasites. Central corneal ulceration is one of the major causes for monocular blindness in developing countries. Corneal scarring is second only to cataract in causing blindness and visual disability in countries as in Asia, Africa, and the Middle East. Keratitis is inflammation of cornea. It can be superficial or deep keratitis. AIM OF THE STUDY: To study the correlation between corneal ulcer parameters measured using slit lamp evaluation and anterior segment optical coherence tomography. OBJECTIVE: To measure corneal ulcer using slit lamp examination and anterior segment optical coherence tomography. METHODOLOGY: A prospective, observational study. New cases of corneal ulcer evaluated in slit lamp and AS OCT by two different observers. Mean length, mean breadth and mean depth of the infiltrate were measured and compared. RESULTS: 76 patients were studied. Mean length of the infiltrate measured using slit lamp and AS OCT were 3.46 ± 1.56 and 3.81 ± 1.47 respectively (r value=0.117; P=0.313). Mean breadth of the infiltrate measured using slit lamp and AS OCT were 3.55 ± 1.73 and 3.98 ± 1.55 respectively (r=0.178;P=0.125). Mean depth of the infiltrate(expressed in percentage) measured using slit lamp and AS OCT were 40.29 ± 18.89 and 49.11 ± 15.19 respectively (r value=0.247;P=0.032). CONCLUSION: AS-OCT measurement values were not in correlation with slit lamp values in our study. Slit lamp bio microscopy consistently underestimated the extent of the corneal ulcer when compared to AS-OCT. However, in cases of peripheral ulcers and deeper ulcers there were practical difficulties in measuring using AS-OCT. Despite the short comings AS-OCT is a non-contact technique that can create high resolution image in a short period of time and help in precise measurement of corneal ulcer parameters. Hence, we conclude that AS-OCT is a valuable adjunct to visualise, measure and monitor in vivo the parameters of corneal ulcers. Further studies are required to determine the viability of using AS-OCT routinely in cases of corneal ulcers.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221713451 |
| Uncontrolled Keywords: | Corneal Ulcer Size, Depth Measurement, Slit Lamp Evaluation, Anterior Segment Optical Coherence Tomography. |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Feb 2021 15:38 |
| Last Modified: | 14 Feb 2021 15:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14202 |
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