Gomathi, A (2016) Morphological changes in red blood cells as a marker of oxidative stress in rheumatoid arthritis and antioxidants as add on therapy to standard treatment in reversal of the changes - a randomized, open label, comparative pilot study. Masters thesis, Madras Medical College, Chennai.
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Abstract
AIM: To evaluate morphological changes in red blood cells due to oxidative stress in patients with Rheumatoid Arthritis and to study the efficacy of Antioxidants(Vitamin C and E) as an add on therapy to standard treatment in the management of these patients compared to standard treatment alone. METHODOLOGY: This was an open label randomised comparative pilot study. In this study 96 patients were screened, 60 patients were included. They were randomly divided into 30 each in study and control group. Control group received T. Hydroxy chloroquine 400mg OD and T. Indomethacin 25 mg BD (standard treatment), study group received standard treatment plus T. Vitamin C 500mg + C. Vitamin E 400mg for 8 weeks. They were followed for 4 weeks. Improvement of patients was monitored by RBC morphological assessment, pain by visual analogue scale, tender joint score, swollen joint score, Disease activity score 28, Inflammatory markers (ESR, CRP), and haemoglobin level every 4 weeks till 12 weeks. RESULTS: All the 60 patients included in this study completed the study. After 8 weeks of treatment in the study group there is statistically significant improvement in pain score, tender joint score, swollen joint score and DAS score. Similarly, statistically significant reduction in inflammatory markers like ESR, CRP and significant improvement in Haemoglobin level were seen. In the follow up period the improvement in study group was sustained. CONCLUSION: RBC morphology as a biomarker of oxidative stress and adding antioxidant to regular treatment is cost effective and novel approach to the treatment of Rheumatoid arthritis.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Rheumatoid Arthritis ; Oxidative Stress ; Anti-Oxidants. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Punitha K |
| Date Deposited: | 11 Jul 2017 06:22 |
| Last Modified: | 08 Nov 2018 05:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1420 |
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