Sharmila, S (2020) A Prospective Observational study to analyze changes in retinal blood vessel density in primary open angle glaucoma following intra ocular pressure reduction by surgical management using optical coherence tomography angiography. Masters thesis, Christian Medical College, Vellore.
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Abstract
INTRODUCTION: Glaucoma is an important leading cause of irreversible blindness worldwide. It is a chronic progressive optic neuropathy with multifactorial pathogenesis, raised intraocular pressure (IOP) being the most widely recognized and the only modifiable risk factor. OBJECTIVES: 1. To document the peripapillary, papillary and optic nerve head vascular density index by using OCT-A, in patients with POAG and cataract before and after PhacoTrab. 2. To document the peripapillary, papillary and optic nerve head vascular density index by using OCT-A, in patients with cataract alone before and after PhacoIOL. METHODS: . OCT-A(using the Swept source spectral domain optical coherence tomography) scan for analysis of the optic nerve head vasculature, peripapillary, papillary and macular vessel density were done at preop, 1 week, 1month and 3 months. The continuous variables among the two groups were compared using independent-t-test and the categorical variables were compared using chi-square test. Repeated measures ANOVA was used to compare the change of variables from baseline to 3 months among the two groups. The pairwise comparison was done with TUKEY test. All the analyses were performed using STATA/ IC 15.0 software. RESULTS: A total of 73 eyes of 73 patients were studied. Of these 33 eyes were of patients with primary open angle glaucoma with immature cataract (PhacoTrab group) and 40 eyes were of patients with immature cataract (PhacoIOL group). Of the 33 patients in the PhacoTrab group, 3 patients did not complete 3-month followup. CONCLUSION: • There was a significant difference in retinal vascular density in the optic nerve head, papillary, peripapillary and macular areas between patients in the PhacoTrab group and PhacoIOL group using Swept source OCTA. • There was a significant improvement in optic nerve head vessel density using Swept source OCT after significant IOP reduction following phacotrabeculectomy. Significant IOP reduction after phacotrabeculectomy did not improve vessel density in papillary, peripapillary and macular areas. • Macular vessel density was preserved even in advanced glaucoma.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221713305 |
| Uncontrolled Keywords: | retinal blood vessel density, primary open angle glaucoma, intra ocular pressure reduction, surgical management, optical coherence tomography angiography. |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Feb 2021 14:21 |
| Last Modified: | 14 Feb 2021 14:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14193 |
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