Jayaprabha, B (2020) A Comparative study of Blood Flow Velocities in Ophthalmic Artery in Glaucoma Patients. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.
|
Text
220301020jayaprabha.pdf Download (11MB) | Preview |
Abstract
BACKGROUND: Glaucoma is a multifactorial optic neuropathy characterized by progressive damage of optic nerve fibers leading to typical optic nerve changes and field defects with or without raise in intraocular pressure. In this study Colour Doppler imaging of the retrobulbar blood vessels is done to assess the role of vascular factors in the pathogenesis of optic nerve fiber damage. AIMS AND OBJECTIVES: 1. To measure and compare the systolic and diastolic blood flow velocities, resistance index in Ophthalmic artery, Central retinal artery and Short posterior ciliary artery in patients with Normotensive glaucoma, untreated Primary Open angle glaucoma and normal subjects. 2. To assess the significance of vascular flow in glaucomatous optic nerve damage. 3. To correlate between optic nerve head blood flow and glaucomatous optic nerve head changes. METHODOLOGY: A prospective cross sectional study to assess the Peak systolic velocity, End diastolic velocity and Resistance Index using Colour Doppler imaging of the retrobulbar vessels was done in 90 subjects during the period December 2017 to June 2019. The 90 subjects were grouped as follows: Group 1: Normotensive glaucoma - 30 patients, Group 2: Untreated primary open angle glaucoma - 30 patients, Group 3: Normal subjects - 30 controls. RESULTS: Compared with normal group, there is significant reduction in PSV (p= 0.0005) in both Normotensive glaucoma and Primary open angle glaucoma group in all the three arteries, namely Ophthalmic artery, Central retinal artery and Short posterior ciliary artery. There is also significant reduction in EDV (p=0.0005) in both the groups in all the three arteries. Increased RI is found in all the three arteries (Ophthalmic artery, Central retinal artery and Short posterior ciliary artery) and is found to be statistically significant in the normotensive and primary open angle glaucoma group with p value of 0.0005. CONCLUSION: In this comparative study of both normotensive and primary open angle glaucoma patients using Colour Doppler imaging to assess the blood flow velocities in Ophthalmic artery, Central retinal artery and Short posterior ciliary artery, it was noted that these vessels had reduced systolic and diastolic blood flow velocity and also increased resistance index. All these factors are known to contribute to the vascular compromise leading to ischemia of the optic nerve head resulting in optic nerve damage. This study concludes that, irrespective of the intraocular pressure, vascular factors do have a role in the pathogenesis of optic nerve head changes in both normotensive and primary open angle glaucoma.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221713601 |
| Uncontrolled Keywords: | Colour doppler imaging, normotensive glaucoma, peak systolic velocity, end diastolic velocity, resistance index. |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Feb 2021 13:31 |
| Last Modified: | 14 Feb 2021 13:31 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14187 |
Actions (login required)
 |
View Item |
