Thendral, V (2020) Clinical study on Orbital Space Occupying Lesions. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
BACKGROUND: Space-occupying lesions, both benign and malignant, cause significant functional and anatomical problems. Intra orbital space occupying lesions can result in double vision, exophthalmos, ptosis, loss of vision, limited action of extraocular movements and even permanent visual loss. AIM OF THE STUDY: 1. To study the clinical & histopathological Etiology of orbital space occupying lesions. OBJECTIVES: 1. To study the Etiology, 2. To study the Radiological features (CT/MRI/B scan). 3. To study the Treatment modalities & Prognosis over one year follow up period. MATERIALS AND METHODS: Study Design: Observational prospective cohort study. Sample size: 35. The study will include patients of all age groups who are presenting in the Department of Ophthalmology, Tirunelveli Medical College, and they will be subjected to, Informed written consent, Detailed history regarding age, sex, duration of complaints, including history of trauma, infection, ocular co morbidities . Previous treatment history and systemic illness. Visual acuity assessment, slit lamp examination, fundus examination, extra ocular movement assessment, Intraocular pressure measurement using Goldman applanation tonometry and differential tonometry. CT, MRI, & B scan will be taken if necessary. Histopathological examination and immunohistochemistry will be checked if needed. Treatment options like surgery, chemotherapy, Radiotherapy, surgery with chemotherapy, surgery with radiotherapy will be done depending upon the diagnosis. Patients will be followed up on 3months, 6months, 1year and their visual acuity, colour vision, extraocular movements, anterior segment and fundus examination prognosis will be assessed. Inclusion Criteria: All age group including both males and females presenting with unilateral and bilateral orbital swelling. Exclusion Criteria: Patient with History of trauma Patient with Orbital infections / Inflammation Patient who are not willing to participate in the study. Eyelid swellings/tumours not extending into orbit. RESULTS: ◆ In my study the most common age group involved is 40-60 years. ◆ In my study males were more than females. ◆ Most of the benign tumours presented under 60 years of age and most of the malignant tumours above 60 years of age. ◆ Most of the IOSOL (Intraorbital space occupying lesions) are unilateral in presentation. ◆ There was no statistical significance in involvement of right eye or left eye. ◆ In my study, the most common presenting complaint is proptosis. Rarely they may also presented with epistaxis, Ptosis and white reflex as the only presenting complaint. ◆ Of the location of IOSOL, majority of the tumour are located in extraconal space compared with intraconal space. ◆ Both benign and malignant tumour were almost equal in number. ◆ Most common benign tumour is Dermoid followed by optic nerve meningioma. ◆ Most common malignant tumour is lymphoma and maxillary carcinoma extending into orbit. ◆ Though Retinoblastoma is a rare tumour, timely diagnosis and management is important to prevent distant metastasis. CONCLUSION: A multimodal workup protocol for IOSOL would ensure early definitive diagnosis. The choice of appropriate treatment is the key to a good survival rate as in our study.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221713253 |
| Uncontrolled Keywords: | Orbital Space Occupying Lesions, proptosis, Retinoblastoma, Dermoid, meningioma, chemotherapy, Radiotherapy. |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Feb 2021 13:16 |
| Last Modified: | 14 Feb 2021 13:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14185 |
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