Anupama, Vinupal (2020) An Analytical study on the Ocular Manifestations in Patients with Autoimmune Blistering Skin Disorders in a Tertiary Care Hospital. Masters thesis, Coimbatore Medical College, Coimbatore.
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Abstract
INTRODUCTION: Autoimmune blistering skin diseases are a heterogenous group of diseases that have as their common feature autoantibodies directed against desmosomal structural proteins. The cell–cell and cell–basement membrane adhesion in the epidermis of the skin is responsible for the resistance of the skin against environmental influences; epidermal integrity is required for protection of the entire organism against mechanical, physical, or microbial insults. The major cellular structures involved are the desmosomes at cell- cell junctions in the epidermis and the hemidesmosome–basement membrane adhesion complexes and related structures at the dermal– epidermal junction. AIMS AND OBJECTIVES: To evaluate the spectrum of ocular manifestations occurring in patients with autoimmune blistering skin disorders and to analyse if early ophthalmological evaluation will be beneficial in reducing the visual morbidity associated with these conditions. MATERIALS AND METHODS: This is a hospital based analytical study involving 100 patients diagnosed as having autoimmune blistering skin diseases. After obtaining written consent, detailed present and past history was recorded. The patients were then subjected to comprehensive ophthalmological examination including uncorrected and best corrected visual acuity, intraocular pressure measurement, slit lamp examination with ocular surface staining, Schirmer’s test, tear film breakup time and fundus examination. RESULTS: Collected data were analysed using frequency analysis, percentage analysis, S.D, mean and Chi-square test. The most common bullous disorder encountered in our study was pemphigus and its variants, of which pemphigus vulgaris was the most common accounting for 47%. The most common ocular manifestation in our study was dry eye (37%) followed by conjunctivitis (17%). Among dry eye patients, moderatesevere dry eye was common; among those with conjunctivitis, noncicatrizing conjunctivitis was common. Cicatrizial manifestations such as symblepharon and conjunctival scarring were also encountered. 5 patients had steroid induced presenile cataract. CONCLUSION: A range of ocular manifestations were encountered in patients with autoimmune blistering skin diseases. Though we did not encounter any vision threatening manifestations in our study, sight threatening complications can occur in untreated patients. A thorough ophthalmological examination and periodic review is thus essential in all patients of autoimmune blistering skin diseases.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221713201 |
| Uncontrolled Keywords: | Ocular Manifestations, Autoimmune Blistering Skin Disorders, Tertiary Care Hospital. |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Feb 2021 12:26 |
| Last Modified: | 14 Feb 2021 12:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14180 |
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