Gangadevi, M (2016) A comparative study of synbiotic as an add on therapy to standard treatment in patients with aggressive periodontitis. Masters thesis, Madras Medical College, Chennai.
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Abstract
AIM: To evaluate the efficacy and safety of Synbiotic as an add on therapy to Standard treatment inthe management of patients with Aggressive Periodontitis compared to Standardtreatment alone. METHODOLOGY This was arandomized, prospective, placebo controlledstudy.60 patients with Aggressive Periodontitis wererandomized and blinded into two groups of 30 each. Control group received Scaling and Root planing [SRP] +Cap.Doxycycline 100mg twice daily for one week +Placebo one lozengetwice daily for 8 weeks andStudy group receivedScaling and Root planing [SRP] +Cap.Doxycycline 100mg twice daily for one week +Synbioticone lozenge twice daily for 8 weeks.The clinical parameters were recorded at baseline, 4,8 and 12 weeks.Oral hygiene index[OHI],Gingival bleeding index[GBI],Probing depth[PD] and Clinical attachment loss[CAL] were assessedat baseline and at the end of the study. RESULTS 106patients were screened out of which 60 patients were included in the study.All patients completed the study and were included in analysis.On comparing the groups at the end of12weeks there was a statistically significant reduction (P<0.01) inOHI,GBI,PD & CALin Study group. No significant difference in the incidence of adverse events noted between the two groups. CONCLUSION Synbioticalong with standard therapy is highly efficacious in reducingOHI,GBI,PD & CALinpatients with Aggressive Periodontitis.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Synbiotic ; Aggressive Periodontitis ; Probing Depth ; Clinical Attachment Loss. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Punitha K |
| Date Deposited: | 11 Jul 2017 05:45 |
| Last Modified: | 08 Nov 2018 04:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1418 |
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