Factors determining short term graft function in Renal Transplant Recipients.

Jayalakshmi, S (2008) Factors determining short term graft function in Renal Transplant Recipients. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : The first successful kidney transplants in humans were from identical twin living donors. Although transplanted before the development of chemical immunosuppression, many of these identical twin grafts had long-term survival. With recognition of the immunosuppressive effects of prednisone and azathioprine, the use of non twin donors became possible. Considerable controversy soon followed as to whether it was ethical to use living donors for kidney transplantation. Proponents of the use of living donors noted that the short and long-term patient and graft survival rates were better after living (vs. cadaver) donor transplants. Opponents worried that living donor nephrectomy was a major operation with potential risk to the donor; they believed that these risks did not justify the benefits to the recipient. The biggest challenge in transplantation today is increasing the number of available organs. However, in the past 2 years, the number of living donor transplants in the United States has increased. Much of this increase followed the recognition that living unrelated donor recipients had out-comes similar to those of living related non-HLAidentical donor recipients. OBJECTIVES : To determine the factors that influence graft functioning at 1 year in live related Donor Renal Transplant. CONCLUSIONS : 1. Donor age influenced graft function at 1year significantly. 2. Discharge creatinine influenced graft function significantly. 3. Donor GFR was significantly associated with graft function at 1 year. 4. Even though Intra operative hypotension had an influence on graft function at 1 year, it was not statistically significant. 5. Events such as Acute Rejections, and Graft Dysfunction during the first year significantly influenced graft function at 1 year. 6. Recipient Age, First day urine output and time taken to reach normal creatinine post operatively were not significantly associated with graft function at 1 year.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Factors determining ; short term ; graft function ; Renal Transplant Recipients.
Subjects: MEDICAL > Nephrology
Depositing User: Kambaraman B
Date Deposited: 11 Jul 2017 04:23
Last Modified: 11 Jul 2017 04:23
URI: http://repository-tnmgrmu.ac.in/id/eprint/1411

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