Dinesh, M (2020) A Comparative study of Topical Platelet Derived Growth Factor (RH-PDGF) Versus Hydrogel Versus Normal Saline Dressing for Treating Diabetic Foot Ulcers. Masters thesis, ESIC Medical College & PGIMS & R, Chennai.
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Abstract
Diabetic foot ulcers remain a major cause of morbidity. Lower Extremity ulcers are serious complications of DM which account for more than 60% of all non-traumatic lower leg amputations. 15% of Diabetic patients will develop foot ulcer during their life time. 6-40% of them may require an amputation. Significant progress has been accomplished in ulcer healing by improved management of both ischemia and neuropathy in the diabetic foot. Nevertheless, there is a vital need for further improvement. Becaplermin gel represents an important therapeutic advance for diabetic neuropathic foot ulcers with adequate blood supply. Randomized controlled trials have shown that it is effective in increasing healing rates. However, this efficacy has not translated to positive clinical experience, and the drug is not widely used. Moreover, becaplermin is an expensive medication. Even though it has repeatedly been estimated as cost-effective, its high cost may be prohibitive for some clinicians, especially in developing countries. Clearly, further work is needed to clarify whether use of becaplermin is justified in everyday clinical practice. Future research also needs to assess the potential room for improvement with becaplermin, for instance by combination with other growth factors or by exploring alternative modes of drug delivery.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221711603 |
| Uncontrolled Keywords: | Growth factor, Hydrogel dressing, Becaplermin, diabetes mellitus, diabetic foot, Ulcer foot, PDGF. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Feb 2021 18:11 |
| Last Modified: | 12 Feb 2021 18:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14085 |
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