Abinandha, M (2020) A Study on Trucut Biopsy in Adenomatous Goitre Specimen in differentiating Follicular Adenoma from Carcinoma. Masters thesis, K.A.P. Viswanatham Government Medical College, Tiruchirappalli.
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Abstract
INTRODUCTION: Thyroid is the largest of all endocrine glands and it is superficial in location.The thyroid gland is affected by various morphologies like developmental, inflammatory, hyperplastic and neoplastic pathology which are common in clinical practice.Fine needle aspiration cytology has been the investigation of choice in thyroid lesions. However FNAC cannot differentiate between follicular adenoma and carcinoma. Trucut biopsy is a well tolerated and reliable procedure for providing a tissue diagnosis of malignancy before planning definitive treatment.Hence a study on diagnostic accuracy of trucut biopsy in differentiating follicular adenoma from carcinoma is done in MGMGH,Trichy. AIM OF THE STUDY: 1. To study the diagnostic accuracy of trucut biopsy in adenomatous goitre specimen in differentiating follicular adenoma from carcinoma. 2. To assess the advantage of trucut biopsy over fine needle aspiration cytology in diagnosing benign and malignant lesions. 3. To evaluate the accuracy of trucut biopsy in adenomatous goitre specimen in correlation with gross specimen report following surgery. METHODOLOGY: A cross sectional study titled “Study on trucut biopsy in adenomatous goitre specimen in differentiating follicular adenoma from carcinoma” was planned with a objective of evaluating the diagnostic accuracy of trucut biopsy in differentiating follicular adenoma from carcinoma at Department of surgery, K.A.P. Viswanatham Government Medical College, Tiruchirappalli and MGMGH, Trichy. Study area: K.A.P. Viswanatham Government Medical College, Tiruchirappalli and MGMGH, Trichy. Study Design: Descriptive study. Study Population: 50 Adenomatous goitre patients Study Duration: 2 Years. Sampling method: Simple random sampling. Study tool: Clinical examination,USGneck,FNAC,Trucut biopsy and HPE. INCLUSION CRITERIA: 1. Age between 20 and 50 years. 2. Euthyroid patients with/without antithyroid drugs. 3. USG/CT confirmation of adenomatous goitre. EXCLUSION CRITERIA: 1. Previous thyroid surgery, 2. On anticoagulant therapy, 3. FNAC features suggestive of thyroiditis. Ethical committee cleareance was obtained before the start of the study. All the patients were subjected to detailed clinical examination. USG neck and FNAC done to make a provisional diagnosis. The patients were advised surgery after detailed investigations and examination. Trucut biopsy was done on the removed part of the gland and gross specimen was also sent for HPE and diagnosis. After reporting, the trucut biopsy reports were decoded and the trucut biopsy report was compared with the HPE report to find the association between both. RESULTS: Around 74% of study population were in the age group of 31-60%. Around 94% of the study population were females. Around 42% of study population had swelling for less than one year. Around 34% of the study population had swelling for 1-2 years duration. Around 60% of the study population had solitary nodule of which right side was two third. Trucut biopsy diagnosed everyone as having follicular adenoma HPE revealed 94% had follicular adenoma while 6% had carcinoma. CONCLUSION: This study was undertaken to find out the diagnostic accuracy of trucut biopsy as against HPE done after surgery in adenomatous goitre patients in differentiating follicular adenoma from carcinoma. The ability of trucut biopsy in correctly identifying those who have follicular carcinoma is zero. Hence like FNAC, eventrucut biopsy was not able to differentiate between follicular adenoma and carcinoma.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221711551 |
| Uncontrolled Keywords: | Thyroidgland, FNAC, Follicularadenoma, Follicularcarcinoma, Trucutbiopsy, USGneck, HPE. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Feb 2021 17:10 |
| Last Modified: | 12 Feb 2021 17:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14070 |
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