Soundrapandiyan, A (2020) A Study on Incidence of Malignancy in Thyroid Nodules. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.
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Abstract
INTRODUCTION: A thyroid nodule is a discrete and radiographically definable lesion within the thyroid. Many thyroid nodules are not palpable, and not all palpable thyroid lesions correspond to a distinct radiographically definable lesion. Only findings truly definable radiographically may be classified as a thyroid nodule. Thyroid nodules are very common with an estimated prevalence of 1% to 5% for palpable nodules. This prevalence is higher when considering nodules detected on imaging. The incidence of thyroid malignancy is raising. Thyroid cancers occurs in 5%to 15% of thyroid nodules. AIM OF THE STUDY: The aim of the study is to determine the incidence of thyroid nodules in relation to age and sex of the patient turning out to be malignancy. OBJECTIVES: PRIMARY OBJECTIVE: To find out the incidence of malignancy in benign thyroid disorders in patients who get admitted and operated in PSG Institute of Medical Sciences and Research, Coimbatore. SECONDARY OBJECTIVE: 1. To find out the demographic difference in patients presenting with malignancy in benign thyroid disorders. 2. To find out % of recurrence in these patients in the study group. 3. To find out the histological types of malignancy in the study group. MATERIALS AND METHODS: • Study Design : Observational study. • Study Population : Individuals who got admitted in surgery ward with thyroid nodule (solitary thyroid nodule, MNG, Hashimotos and other types) and operated at PSG Institute of Medical Sciences and Research ,Coimbatore. • Study Locality: PSG Institute of Medical Sciences and Research, Coimbatore. • Sample Size: 151. • Retrospective analytical study will be carried out from period of January 2014 to December 2017 by collecting old case files from MRD. • Details of patients demographics ,clinical presentation and diagnosis, results of FNAC ,USG findings, gross features and biopsy results of the resected thyroid specimens are obtained from patients case files. • H& E stained slides of the thyroidectomy specimens were analyzed by an independent pathologist. Histopathological diagnosis will be considered as gold standard. Parameters for assessment: Clinical details(age,sex), gross and microscopic picture of all thyroid malignant tumors,will be discussed individually.The following statistical tests will be performed. 1. Chi sqare test, 2. Ratio, 3. Percentage. RESULTS: Out of 151 patients with benign thyroid nodule, 15 were found to develop malignancy (10%) , in which 14 had papillary carcinoma of thyroid and 1 had hurtle cell carcinoma. There was statistically significant association between age and malignancy. Out of 76 patient of solitary nodular goitre 10 patient found to be malignant and out of 75 multi nodular goitre 5 found to be malignant histopathologically. CONCLUSION: From this study we have concluded that the incidence of thyroid malignancy in benign thyroid disorder is 10%. Therefore Incidence of malignancy in solitary nodular goitre is higher compared to multinodular goitre.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221711502 |
| Uncontrolled Keywords: | Incidence, Malignancy, Thyroid Nodules. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Feb 2021 17:01 |
| Last Modified: | 12 Feb 2021 17:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14068 |
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