Sri Priyadharsan, V (2020) A Prospective study on Procalcitonin as an Useful Biomarker for Prognosis of Sepsis and Guide for Antibiotic Therapy in SICU Patients. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.
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Abstract
INTRODUCTION: Sepsis is most common cause of death in surgical ICU patients. Early diagnosis and appropriate antibiotics plays the major role in saving the patients. Procalcitonin helpful in early detection as well as to monitor the anti microbial therapy. AIMS AND OBJECTIVES: To study on effectiveness of procalcitonin as a useful biomarker for prognosis of sepsis and guide for antibiotic therapy in SICU patients. MATERIAL AND METHODS: Cases admitted to GMKMC hospital Salem with signs of sepsis in SICU patients will be closely monitored from the day of admission to the day of discharge. On an average of 100 cases with signs of sepsis in ICU patients admitted between 2017 to 2019. RESULTS: A prospective study on Procalcitonin as a useful biomarker for prognosis of sepsis and guide for antibiotic therapy in SICU patients revealed the following findings.The mean age is 57.06 years with a standard deviation of 9.39 years. The median age is 56 years ranging between 38 years and 74 years. The majority of the participants were males (n=56, 56%) while the rest were females. Out of the 100 patients, 76 of them (76%) were blood culture positive while the remaining 24%were blood culture negative. Out of the 100 patients, 68 of them (68%) were pus culture positive while the remaining 32% were pus culture negative. Out of the 100 patients, 80 of them (80%) were urine culture positive while the remaining 20% were urine culture negative. Out of the 100 patients, 66 of them (66%) were wound swab positive while the remaining 34% were wound swab negative. Out of the 100 patients, 42 of them (42%) were Klebsiella positive while 34 of them (34%) were E.coli positive. Pseudomonas was positive in 14% (n=14) of them while Proteus was present in 8% (n=8) of them. The organisms were sensitive to Piptaz (n=50, 50%) and Cefaperazone (n=48, 48%). CRP was positive in 47% of the cases and negative in 53% of the cases. Procalcitonin is 100% sensitive and specific in predicting the prognosis in patients of surgical ICU. CONCLUSION: CRP was positive in 47% of the cases and negative in 53% of the cases. Procalcitonin is 100% sensitive and specific in predicting the prognosis in patients of surgical ICU. The levels of procalcitonin in sepsis rises rapidly and tends to peak sooner than CRP. They also return to baseline sooner in response to treatment. Either ways, procalcitonin can be used to detect sepsis and also the response to treatment. This is why, it is an ideal candidate as a biomarker in sepsis.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221711409 |
| Uncontrolled Keywords: | Sepsis, Procalcitonin, CRP. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Feb 2021 16:05 |
| Last Modified: | 12 Feb 2021 16:05 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14057 |
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