Kaviya, N (2020) A Prospective study on the Efficacy of CECT Abdomen, Histopathological Examination and Cartridge Based Nucleic Acid Amplification Test in Predicting Abdominal Tuberculosis in Government Mohan Kumaramangalam Medical College Hospital, Salem. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.
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Abstract
BACKGROUND: Despite continuous and varied efforts, "Tuberculosis has come back with a vengeance in various parts of the world”. Multiple investigation techniques were available for the diagnosis of abdominal tuberculosis including ultrasonography, CT abdomen, Capsule endoscopy and enteroscopy, Ultrasound guided Fine needle aspiration, Histopathology, Nucleic acid amplification, Gene Xpert assay etc. OBJECTIVE: To compare the efficacy of CECT abdomen, catridge based nucleic acid amplification test and histopathological examination in predicting abdominal tuberculosis. METHODOLOGY: The present study was a prospective observational study carried out in the department of general surgery, Government Mohan Kumaramangalam Medical College and Hospital located in Salem, Tamilnadu. The study was conducted between 2017 to 2019. All the persons who were admitted into the surgery ward during the study period with clinical diagnosis of abdominal tuberculosis were enrolled into the study. To all the study participants with appropriate indications either CECT abdomen or CBNAAT or both were administered. Histopathological examination were also performed in indicated persons. Diagnosis from all the three modalities were recorded. Sensitivity, specificity, diagnostic accuracy were calculated among those in whom all three modalities were administrated. RESULTS: The sensitivity of CECT abdomen was found to be 83.3% and the specificity was 66.6%. The diagnostic accuracy was found to be 80.6%. The sensitivity of CBNAAT was found to be 63.3% while the specificity was found to be 83.3%. The diagnostic accuracy of CBNNAT was found to be 66.7%. CONCLUSION: CECT abdomen is more a screening tool for abdominal tuberculosis and CBNAAT though can be looked upon as diagnostic tool, the low sensitivity should be scrutinized. Other advantages of CBNAAT like rapidity of testing, decentralization and finding resistance would come to its aid.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221711405 |
| Uncontrolled Keywords: | CECT abdomen, CBNAAT, Histopathology, Sensitivity, specificity, Diagnostic accuracy. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Feb 2021 15:34 |
| Last Modified: | 12 Feb 2021 15:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14053 |
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