Suraj, Kumar (2013) Hyperuricemia in Renal Allograft Recipients. Masters thesis, Christian Medical College, Vellore.
|
Text
160301113surajkumar.pdf Download (2MB) | Preview |
Abstract
INTRODUCTION : Hyperuricemia has been commonly associated with renal and cardiovascular diseases. In patients with gout, before the availability of antihyperuricemic treatment, 25% of patients developed proteinuria, 50% had chronic kidney disease, and 10–25% had end stage kidney disease. It is also more commonly seen in individuals with hypertension, obesity, metabolic syndrome etc. Over the years with widespread changes in dietary habits, there has been a worldwide epidemic of hyperuricemia, metabolic syndrome, obesity and type- 2-diabetes. The animal models and experimental studies have further strengthened this association. AIM / OBJECTIVES : The primary objective was to assess the prevalence, clinical and biochemical predictors of hyperuricemia in renal allograft recipients. The secondary objective was to find association of graft function with hyperuricemia. MATERIAL AND METHODS : We conducted a retrospective study on 283 renal allograft recipients with at least 6 month follow up. The data was recorded for each month till 6months and at 12th and 18th month and thereafter annually. We determined eGFR and occurrence of hyperuricemia, dyslipidemia, NODAT, acute rejection episodes. Hyperuricemia was defined as >6mg/dl in women and >7mg/dl in men and subdivided into early and late onset (<1>year) and mild and moderate to severe (<8>mg/dl). The statistical analyses were performed using SPSS software and independent t-test and Fisher’s exact test or chi square test were performed depending on variables. RESULTS : The prevalence of hyperuricemia was 26.8%. The mean time to onset of hyperuricemia was 6mths. Majority of the patients had early hyperuricemia (<12 months). Early onset moderate to severe hyperuricemia was seen in 29.5%. The incidence of NODAT and Dyslipidemia was 22% and 42% respectively. The nadir eGFR(73.0±27.5ml/min vs. 81.9±30.9ml/min, p value 0.03) and estimated GFR at 1month (68.5±21.0ml/min vs. 74.5±20.6ml/min, p value 0.04) were lower in patients with hyperuricemia.The incidence of NODAT (12.7% vs. 50.7%, p value 0.00) and serum triglyceride levels were higher (150.2±67.5mg/dl vs. 131.9±39.5mg/dl, p value 0.037) in patients with hyperuricemia. The recipients who had early onset moderate to severe hyperuricemia were found to have a lower estimated GFR at 1year (65.2±18.8 vs. 78.2±19.4, p value 0.014)where as early onset mild hyperuricemia had no association with GFR at any time interval. CONCLUSIONS : The prevalence of hyperuricemia was 26.8%. Hyperuricemia was associated with a higher BMI at transplant, lower graft function, presence of NODAT and higher triglyceride levels. There was no association with recipient gender, deceased donor allograft or acute rejection episodes.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Hyperuricemia ; renal ; allograft ; recipients. |
| Subjects: | MEDICAL > Nephrology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 11 Jul 2017 07:41 |
| Last Modified: | 11 Jul 2017 07:41 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1405 |
Actions (login required)
 |
View Item |
