Naveen Kumar, M (2020) A Comparative study of Single Dose Preoperative Ceftriaxone and Routine Conventional Postoperative Prophylaxis in Elective General Surgical Cases. Masters thesis, Coimbatore Medical College, Coimbatore.
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Abstract
INTRODUCTION: Surgical site infection (SSI) is defined by Centre for Disease Control and Prevention (CDC) as proliferation of microorganisms developing in a surgical incision site within skin and subcutaneous fat (superficial), musculo-fascial layers (deep), or in an organ or cavity. Surgical site infection is a common malady caused due to health care associated infections causing significant postoperative morbidity and mortality. AIM OF THE STUDY: To assess the efficacy of single dose preoperative CEFTRIAXONE compared to multiple doses of postoperative prophylaxis in reducing surgical site infection and to prevent unnecessary development of antimicrobial resistance. MATERIALS AND METHODS: This study includes 50 clean cases randomized to two category of 25 each, like clean group without implant (e.g. Hydrocele) and clean group with implant (inguinal hernia). In each category a single dose of preoperative ceftriaxone is given to study group whereas 3 to 5 days of routine empirical antibiotic prophylaxis is given to control group. Single shot of 1 gm Ceftriaxone is given before half an hour of skin incision or at induction time for all clean class 1 cases in study group and in case if the procedure is prolonged for more than 3 hrs a second dose was given. No further administration of antibiotics is considered in study group. Routine empirical antibiotic prophylaxis is given to control group of inj. Cefotaxime 1Gm IV BD and inj Metronidazole 500mg IV TDS for3- 5 days. The surgical site was inspected daily from second post operative day and was followed up at 8th POD, 15th POD, and 30th POD and later at 3 months and 6 months based on the following criteria for SSI. Complications related to SSI are noted and data is obtained and the results were analysed with both groups. CONCLUSION: Based on my study I would like to conclude that it is recommendable to use single dose preoperative CEFTRIAXONE prophylaxis for all class I, as per the study results there is a significant difference in incidence of SSI when compared to the traditional regimes with the added advantage of significant reduction in hospital stay, with its resultant savings in resources. In addition as the use of antibiotics is reduced it further results in increased cost effectiveness and reduces the incidence of complications due to antibiotic overuse.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221711312 |
| Uncontrolled Keywords: | Surgical Site Infection, Ceftriaxone, Hernia, Hydrocele, Antibiotic Prophylaxis. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 10 Feb 2021 18:09 |
| Last Modified: | 10 Feb 2021 18:09 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14023 |
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