Sujitha, S (2020) A Cross Sectional study on Predictors of Malignancy in Solitary Thyroid Nodule. Masters thesis, Madurai Medical College, Madurai.
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Abstract
INTRODUCTION: Thyroid nodule is a common presentation and requires a structured diagnostic approach to ascertain the risk of malignancy and determine appropriate management. Thyroid nodules can be detected by palpation in 10% of women and 2% of men. The prevalence of thyroid nodules can be 50% or more if ultrasonography (US) is used. Although thyroid nodule is a common presentation, thyroid cancer is rare representing 1% of all cancers. Thyroid cancer has a favorable prognosis and accounts for less than 0.5% of cancer deaths. The well differentiated thyroid cancer (WDTC), which includes papillary and follicular cancer, comprises the vast majority (90%) of all thyroid cancers. A thyroid nodule is defined as a discrete lesion within the thyroid gland that is clinically and radiologically distinct from the surrounding thyroid parenchyma. AIM OF THE STUDY: To evaluate potential role of Thyroglobulin (Tg), thyroid stimulating hormone (TSH) as preoperative indicators of malignancy in thyroid nodule. MATERIALS AND METHODS: Present study is a cross sectional study carried out with a sample size of 49 patients. presenting with the solitary thyroid nodules in the age group 18 to 70 years A detailed note of the clinical size of the nodule/ (as measured clinical and by ultrasound), presence of voice change, age and sex of the patient, results of the FNAC, and final histopathology along with biochemical information such as preoperative thyroglobulin, and serum TSH will be made. Correlation between TSH and Thyroglobulin is assessed statistically. RESULTS: Out of 49 members 42 were found to be benign and 7 were found malignant. TSH level were found to be with mean value of 4.73 in malignant lesion group .TSH level of benign group were with mean value of 1.72.Thus higher mean value of TSH is found in malignant group. P value is found to be <.0005 which is statistically significant and proves higher values of TSH is associated with malignancy. Thyroglobulin level was found to be with mean 24.77 in malignant group & Mean level of 122.92 is found in benign group. Thus thyroglobulin was higher in benign rather than malignant group .Thus in general thyroglobulin is of no value in predictor of malignancy in solitary thyroid nodule. CONCLUSION: higher serum TSH levels are associated with an increased risk of thyroid cancer in patients with thyroid nodules. The use of TSH as an adjunctive diagnostic test for stratifying the risk of malignancy associated with thyroid nodules have value to decision-making on diagnostic approaches. Thyroglobulin does not found to have any correlation with malignancy. But once proven malignant, thyroglobulin can be used as prognostic marker in follow up of cases.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221711164 |
| Uncontrolled Keywords: | Solitary thyroid nodule, Biochemical markers, Thryroglobulin & TSH, predictors of malignancy. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 10 Feb 2021 16:18 |
| Last Modified: | 10 Feb 2021 16:18 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13993 |
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