Rajesh, Joseph (2010) Hepatitis B and Hepatitis C profile in pre and post renal transplant patients from 2002 to 2009: A Single Centre study from Christian Medical College, Vellore. Masters thesis, Christian Medical College, Vellore.
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Abstract
BACKGROUND : Hepatitis B (HBV) and hepatitis C (HCV) viral infections are important causes of morbidity and mortality in hemodialysis and renal transplantation patients and pose problems in the management of these patients. Blood transfusion and duration of hemodialysis are independent risk factors for infectivity. In the Indian subcontinent the prevalence of these infections are high. Therefore to know the current prevalence, risk factors and to improve on preventive measures the current study was undertaken. Treatment for these patients is not satisfactory. OBJECTIVES : To identify the Hepatitis B & C incidence and prevalence in hemodialysis and renal transplantation patients, risk factors involved and the relevance of viral serology, PCR and liver enzymes in predicting the infection and outcome. METHODS : All patients who underwent hemodialysis and renal transplantation from June 2002 to December 2009 were enrolled in the study. All patients underwent viral serology tests which included Hepatitis B surface antigen, Anti hepatitis C antibody and Anti-hepatitis B core antibody. Selected patients underwent Hepatitis B and C PCR testing. Duration of hemodialysis and blood transfusions are well known risk factors, and were therefore analyzed in the study. Post transplantation the prevalence was reassessed. The time required for seroconversion post transplantation, other concomitant infections and outcomes on patient and graft survival were studied. RESULTS : The prevalence of hepatitis B and C increased from 5% and 4.2% in the pre transplantation period to 9% and 7.1% respectively in the post transplantation period. Blood transfusion (external) and duration of dialysis was found to be a significant risk factor for HCV seroconversion pre and post renal transplantation (p <0.001). Patients who are anti HBc positive during the pre transplantation period has a high probability of becoming HBsAg/ PCR positive post transplantation. Statistically significant elevation of liver enzymes was seen only during HCV seroconversion. Graft function and patient survival were not affected.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Hepatitis B ; Hepatitis C ; pre and post renal transplant patients ; 2002 to 2009 ; single centre study ; Christian Medical College, Vellore. |
| Subjects: | MEDICAL > Nephrology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 11 Jul 2017 07:24 |
| Last Modified: | 11 Jul 2017 07:24 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1399 |
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